期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 365, 期 4, 页码 612-617出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202201234
关键词
Photocatalysis; Dehydrative coupling; N-arylacrylamides; Oxindoles; Hydroxyketones
A mild visible-light induced 4CzIPN/H+ photoredox system was developed for the formal C-O bond cleavage of hydroxyketones, serving as a carbon radical precursor. This process was successfully applied in the coupling/cyclization reaction of N-arylacrylamides, providing a practical access to acyl oxindoles. The protocol offers advantages such as no need for any metal catalyst and additive, high yield, broad substrate scope, gram scalability, and sole byproduct release of H2O.
A mild visible-light induced 4CzIPN/H+ photoredox system has been developed that enables hydroxyketones serving as a carbon radical precursor via formal C-O bond cleavage. This process was successfully exploited in the coupling/cyclization reaction of N-arylacrylamides and thereby provided a viable access to acyl oxindoles. This protocol features advantages including no need for any metal catalyst and additive, high yielding, broad substrate scope, gram scalability, and release of H2O as the sole byproduct.
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