期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 364, 期 24, 页码 4402-4408出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202201145
关键词
cascade reaction; furanochromanone skeleton; asymmetric reaction; deformylation; p-quinol
资金
- National Natural Science Foundation of China
- Pearl River Talents Recruitment Program of Guangdong Province
- Science and Technology Program of Guangzhou
- Guangdong Provincial Key Laboratory of Catalysis
- [22001048]
- [2017GC010361]
- [202102020215]
- [2020B121201002]
A DABCO-catalyzed cascade reaction was used to construct furanochromanone skeletons with high yields and diastereoselectivity. The asymmetric catalytic version of this reaction also showed excellent enantio- and diastereoselectivity, producing furanochromanones with multiple stereogenic centers.
An approach for the construction of furanochromanone skeletons has been developed through a DABCO-catalyzed cascade reaction with good yields (up to 83%) and high diastereoselectivity (> 20:1 dr). Notably, the asymmetric catalytic version of this reaction was further studied, obtaining furanochromanones bearing four contiguous stereogenic centers with excellent enantio- and diastereoselectivity (up to 98% ee, > 20:1 dr). This protocol causes the formation of a variety of substituted furanochromanones via an oxaMichael/Michael addition/deformylation cascade reaction.
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