期刊
JOURNAL OF NEUROGENETICS
卷 30, 期 1, 页码 5-15出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/01677063.2016.1144751
关键词
Addiction; attention deficit hyperactivity disorder; dopamine transporter; knockout; Parkinson's disease; schizophrenia
资金
- Russian Science Foundation grant [14-15-00131]
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA022449] Funding Source: NIH RePORTER
- Russian Science Foundation [14-15-00131] Funding Source: Russian Science Foundation
The dopamine transporter (DAT) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. Since brain dopamine is known to be involved in numerous neuropsychiatric disorders, investigations using mice with genetically altered DAT function and thus intensity of dopamine-mediated signaling have provided numerous insights into the pathology of these disorders and novel pathological mechanisms that could be targeted to provide new therapeutic approaches for these disorders. In this brief overview, we discuss recent investigations involving animals with genetically altered DAT function, particularly focusing on translational studies providing new insights into pathology and pharmacology of dopamine-related disorders. Perspective applications of these and newly developed models of DAT dysfunction are also discussed.
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