期刊
JOURNAL OF NEUROGENETICS
卷 30, 期 1, 页码 16-21出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/01677063.2016.1155571
关键词
CYP3A4*22; drug metabolism; EPHX1 gene
资金
- Higher Education and Scientific Research Ministry'' in Tunisia
The aim of this study was to evaluate the impact of polymorphisms in the EPHX1 (c.416A>G, c.337T>C) and CYP3A4*22 genes involved in carbamazepine (CBZ) metabolism and pharmacoresistance among 118 Tunisian patients with epilepsy under maintenance dose of CBZ. These genetic polymorphisms were analyzed by PCR-RFLP. Associations between plasma CBZ concentration, CBZ-E concentration, maintenance doses and metabolic ratio (CBZ-E:CBZ, CBZ-D:CBZ-E) were analyzed with each polymorphism. Both variants of EPHX1 c.416A>G and c.337T>C are significantly associated with higher metabolic ratio CBZ-E:CBZ and seem to decrease the activity of the epoxide hydrolase. The CYP3A4*22 variant allele is significantly associated with lower CBZ-D:CBZ-E ratio and seems also to be associated with less activity of the cytochrome. Our data suggest that certain polymorphisms of metabolizing enzyme genes could influence inter-individual variability of CBZ metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据