A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice

Article Chemistry, Multidisciplinary

Regenerating the Injured Spinal Cord at the Chronic Phase by Engineered iPSCs-Derived 3D Neuronal Networks

Lior Wertheim et al.

Summary: Functional human neuronal network is engineered by mimicking embryonic development of the spinal cord in a 3D dynamic biomaterial-based microenvironment, showing therapeutic potential for regenerating injured spinal cord.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Magnetoelectric Effect in Hydrogen Harvesting: Magnetic Field as a Trigger of Catalytic Reactions

Donghoon Kim et al.

Summary: This study demonstrates the potential use of magnetic fields as an independent energy source for hydrogen harvesting, controlling catalytic reactions through the magnetoelectric effect. The magnetism of composite materials plays a crucial role in sensing and triggering reactions in the environment.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Magnetic Microswarm and Fluoroscopy-Guided Platform for Biofilm Eradication in Biliary Stents

Mengmeng Sun et al.

Summary: Treating biofilm infections on medical implants is challenging, but magnetically driven microrobots show potential for disrupting these harmful biostructures.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability

Seungmin Noh et al.

Summary: This study introduces a biodegradable GelMA microrobot that can be mass-produced in a microfluidic channel. The microrobot shows precise rolling motion in response to an external rotating magnetic field and can release loaded stem cells for proliferation and differentiation after enzymatic degradation.

SMALL (2022)

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Article Biology

Optimized single-step optical clearing solution for 3D volume imaging of biological structures

Kitae Kim et al.

Summary: OptiMuS is an optical clearing method that achieves rapid and high transparency of brain tissues and other intact organs while preserving tissue size and fluorescent signal. It is also compatible with the use of lipophilic dyes to reveal vascular structures and can be applied to pathological analysis of kidneys.

COMMUNICATIONS BIOLOGY (2022)

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Article Pharmacology & Pharmacy

Closed-Loop Temperature-Controlled Magnetic Hyperthermia Therapy with Magnetic Guidance of Superparamagnetic Iron-Oxide Nanoparticles

Awais Ahmed et al.

Summary: This study proposes a closed-loop temperature controller for targeted hyperthermia therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Accurate temperature control is achieved by adjusting the magnetic field strength. The SPIONs can be actively manipulated towards the target using a rotating magnetic field (RMF), followed by exposure to an alternating magnetic field (AMF) for controlled heating. In vitro and in vivo experiments demonstrate the effectiveness of SPIONs in reducing cancer cell viability and tumor volume.

ADVANCED THERAPEUTICS (2022)

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Article Biochemistry & Molecular Biology

Neuroimaging-based brain-age prediction in diverse forms of epilepsy: a signature of psychosis and beyond

Daichi Sone et al.

Summary: A recent study utilized MRI scans to estimate brain-age in patients with epilepsy, finding that all epilepsy categories except extra-temporal lobe focal epilepsy showed a significant increase in brain-predicted age difference. Temporal lobe epilepsy with hippocampal sclerosis showed the highest brain-predicted age difference, while progressive myoclonic epilepsy had a higher brain-predicted age difference than juvenile myoclonic epilepsy. This neuroimaging-based brain-age prediction method provides novel insights into the diverse symptoms of epilepsy.

MOLECULAR PSYCHIATRY (2021)

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Article Neurosciences

Comprehensive Analysis of Long-Range Connectivity from and to the Posterior Parietal Cortex of the Mouse

Seung Wook Oh et al.

Summary: The posterior parietal cortex plays a crucial role in various higher order cognitive functions and integrates inputs from different sensory cortices and subcortical areas to facilitate the execution of functions. Comprehensive understanding of the long-range connectivity of the mouse PPC is still limited, hindering the interpretation of accumulating functional data and effective paths forward for various studies.

CEREBRAL CORTEX (2021)

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Review Chemistry, Multidisciplinary

Trends in Micro-/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

Ben Wang et al.

Summary: This review focuses on the applications of micro-/nanorobots in biomedical engineering, particularly in in vivo diagnosis and intervention. It discusses the design, fabrication, functionalization, actuation, and localization of these robots, as well as their roles in diagnosis, sensing, microsurgery, drug delivery, and wound healing. The review also summarizes the current challenges and future research directions in this field.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Recent Progress in Magnetically Actuated Microrobots for Targeted Delivery of Therapeutic Agents

Junhee Choi et al.

Summary: Magnetically actuated microrobots have made significant progress in targeted therapeutic delivery, offering unique advantages in accessing hard-to-reach lesions in a minimally invasive manner. However, challenges such as low survival rate of transplanted cells and difficulties with administration route remain to be addressed for further advancements in the field.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Robotics

Dual-responsive biohybrid neutrobots for active target delivery

Hongyue Zhang et al.

Summary: Neutrophil-based microrobots, constructed by phagocytosis of drug-loaded magnetic nanogels enveloped in Escherichia coli membrane, exhibit controllable intravascular movement and can autonomously aggregate in the brain by positive chemotactic motion along the gradient of inflammatory factors. These dual-responsive neutrobots show promise for targeted drug delivery to inhibit tumor cell proliferation compared to traditional drug injection, leveraging the biological characteristics of natural neutrophils that artificial microrobots cannot replicate.

SCIENCE ROBOTICS (2021)

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Article Chemistry, Multidisciplinary

Domino Reaction Encoded Heterogeneous Colloidal Microswarm with On-Demand Morphological Adaptability

Dongdong Jin et al.

Summary: This study introduces an adaptive and heterogeneous colloidal magnetic microswarm with cooperative domino reaction encoded functions, which can switch between different swarm states to adapt to various environments, and integrates cooperative tasking capability through division of labor, showcasing coordinated delivery and disruption of cancer cells through specialization and cooperation.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Guiding the Patterned Growth of Neuronal Axons and Dendrites Using Anisotropic Micropillar Scaffolds

Shengying Fan et al.

Summary: The patterning of axonal and dendritic growth is crucial for generating directed neuronal networks in vitro. 3D micropillar scaffolds can guide the growth of neural stem cells and hippocampal neurons, affecting branching and orientation of axons and dendrites. Neurons tend to form functionally connected networks on arrays of micropillars of the same height, showing synchronous neuronal activity.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Engineering, Biomedical

A Magnetically Powered Stem Cell-Based Microrobot for Minimally Invasive Stem Cell Delivery via the Intranasal Pathway in a Mouse Brain

Sungwoong Jeon et al.

Summary: Targeted stem cell delivery using magnetically powered microrobots through intranasal administration shows promise in treating central nervous system disorders in a minimally invasive manner.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Engineering, Biomedical

Poly(α-L-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives

Maochao Zheng et al.

Summary: Poly(alpha-L-lysine) (PLL) is a water-soluble, cationic biopolymer composed of alpha-L-lysine structural units. Over the past decade, significant progress has been made in the synthesis and biomedical applications of PLL, including antibacterial agents, gene/drug/protein delivery systems, bio-sensing, bio-imaging, and tissue engineering. Despite the promising potential of PLL-based nanomaterials in biomedical fields, challenges and perspectives still need to be addressed.

BIOACTIVE MATERIALS (2021)

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Article Engineering, Biomedical

Acoustically Mediated Controlled Drug Release and Targeted Therapy with Degradable 3D Porous Magnetic Microrobots

Jongeon Park et al.

Summary: This magnetically driven porous degradable microrobot (PDM) can be wirelessly actuated by rotating magnetic fields and has enhanced drug release and acoustically induced drug release capabilities. The PDM offers three different drug release modes that can be selected by ultrasound exposure conditions, and the in vitro test results show different therapeutic effects on cancer cells in each release mode.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Biomaterials for Personalized Cell Therapy

Amanda L. Facklam et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

Biofabrication of neural microphysiological systems using magnetic spheroid bioprinting

Devon A. Bowser et al.

BIOFABRICATION (2020)

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Article Chemistry, Multidisciplinary

Pros and Cons: Magnetic versus Optical Microrobots

Metin Sitti et al.

ADVANCED MATERIALS (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Contralateral Preoperative Resting-State Functional MRI Network Integration Is Associated with Surgical Outcome in Temporal Lobe Epilepsy

Matthew N. DeSalvo et al.

RADIOLOGY (2020)

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Article Chemistry, Multidisciplinary

A Patch of Detachable Hybrid Microneedle Depot for Localized Delivery of Mesenchymal Stem Cells in Regeneration Therapy

KangJu Lee et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Clinical Neurology

High Frequency Oscillations in Rat Hippocampal Slices: Origin, Frequency Characteristics, and Spread

Isaac Naggar et al.

FRONTIERS IN NEUROLOGY (2020)

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Article Chemistry, Multidisciplinary

Reduced Graphene Oxide-Encapsulated Microfiber Patterns Enable Controllable Formation of Neuronal-Like Networks

Juan Wang et al.

ADVANCED MATERIALS (2020)

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Article Multidisciplinary Sciences

A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks

Eunhee Kim et al.

SCIENCE ADVANCES (2020)

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Article Materials Science, Biomaterials

Remote Control in Formation of 3D Multicellular Assemblies Using Magnetic Forces

Javad Jafari et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Orthopedics

In Vivo Imaging of Exogenous Progenitor Cells in Tendon Regeneration via Superparamagnetic Iron Oxide Particles

Thomas J. Kremen et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2019)

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Article Robotics

Magnetically actuated microrobots as a platform for stem cell transplantation

Sungwoong Jeon et al.

SCIENCE ROBOTICS (2019)

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Article Biology

HCN Channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

Niklas Byczkowicz et al.

ELIFE (2019)

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Article Engineering, Biomedical

Magnetically Actuated SiCN-Based Ceramic Microrobot for Guided Cell Delivery

Ki-Won Gyak et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Review Chemistry, Multidisciplinary

Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine

Xinlong Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Neurosciences

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Sara Elfarrash et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Long-term in vivo CT tracking of mesenchymal stem cells labeled with Au@BSA@PLL nanotracers

Xinyu Ning et al.

NANOSCALE (2019)

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Review Clinical Neurology

Stereoelectroencephalography in epilepsy, cognitive neurophysiology, and psychiatric disease: safety, efficacy, and place in therapy

Brett E. Youngerman et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2019)

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Article Biochemistry & Molecular Biology

Surface coating affects uptake of silver nanoparticles in neural stem cells

Igor M. Pongrac et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2018)

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Article Nanoscience & Nanotechnology

Highly Stabilized Nanoparticles on Poly-L-Lysine-Coated Oxidized Metals: A Versatile Platform with Enhanced Antimicrobial Activity

Fiorela Ghilini et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Interaction of poly-L-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells

Wei Xiong Siow et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Chemistry, Multidisciplinary

Design of Magnetically Labeled Cells (Mag-Cells) for in Vivo Control of Stem Cell Migration and Differentiation

Seokhwan Yun et al.

NANO LETTERS (2018)

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Article Neurosciences

Synaptic transmission and excitability during hypoxia with inflammation and reoxygenation in hippocampal CA1 neurons

Yoon-Sil Yang et al.

NEUROPHARMACOLOGY (2018)

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Article Chemistry, Multidisciplinary

A Fully 3D Interconnected Graphene-Carbon Nanotube Web Allows the Study of Glioma Infiltration in Bioengineered 3D Cortex-Like Networks

Miao Xiao et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Multidisciplinary

In Vivo Micro-CT Imaging of Human Mesenchymal Stem Cells Labeled with Gold-Poly-l-Lysine Nanocomplexes

Taeho Kim et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Article Robotics

Multifunctional biohybrid magnetite microrobots for imaging-guided therapy

Xiaohui Yan et al.

SCIENCE ROBOTICS (2017)

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Article Nanoscience & Nanotechnology

Superparamagnetic Iron Oxide-Loaded Cationic Polymersomes for Cellular MR Imaging of Therapeutic Stem Cells in Stroke

Xiaohui Duan et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2016)

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Article Nanoscience & Nanotechnology

Nano-patterned SU-8 surface using nanosphere-lithography for enhanced neuronal cell growth

Eunhee Kim et al.

NANOTECHNOLOGY (2016)

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Article Biochemical Research Methods

A decade of progress in tissue engineering

Ali Khademhosseini et al.

NATURE PROTOCOLS (2016)

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Article Nanoscience & Nanotechnology

Surface coating affects behavior of metallic nanoparticles in a biological environment

Darija Domazet Jurasin et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2016)

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Article Neurosciences

Multiple Single-Unit Long-Term Tracking on Organotypic Hippocampal Slices Using High-Density Microelectrode Arrays

Wei Gong et al.

FRONTIERS IN NEUROSCIENCE (2016)

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Article Multidisciplinary Sciences

Electrical Identification and Selective Microstimulation of Neuronal Compartments Based on Features of Extracellular Action Potentials

Milos Radivojevic et al.

SCIENTIFIC REPORTS (2016)

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Article Chemistry, Multidisciplinary

An effective strategy of magnetic stem cell delivery for spinal cord injury therapy

Dmitry Tukmachev et al.

NANOSCALE (2015)

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Article Cell Biology

Restoring nervous system structure and function using tissue engineered living scaffolds

Laura A. Struzyna et al.

NEURAL REGENERATION RESEARCH (2015)

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Article Nanoscience & Nanotechnology

Highly Efficient Labeling of Human Lung Cancer Cells Using Cationic Poly-L-lysine-Assisted Magnetic Iron Oxide Nanoparticles

Xueqin Wang et al.

NANO-MICRO LETTERS (2015)

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Article Nanoscience & Nanotechnology

Highly Efficient Labeling of Human Lung Cancer Cells Using Cationic Poly-L-lysine-Assisted Magnetic Iron Oxide Nanoparticles

Xueqin Wang et al.

NANO-MICRO LETTERS (2015)

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Article Physics, Applied

Behavior of rotating magnetic microrobots above the step-out frequency with application to control of multi-microrobot systems

Arthur W. Mahoney et al.

APPLIED PHYSICS LETTERS (2014)

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Article Engineering, Biomedical

Magnetic-directed patterning of cell spheroids

Benjamin R. Whatley et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2014)

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Article Biochemical Research Methods

Generation of cerebral organoids from human pluripotent stem cells

Madeline A. Lancaster et al.

NATURE PROTOCOLS (2014)

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Article Multidisciplinary Sciences

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Douglas J. Bakkum et al.

NATURE COMMUNICATIONS (2013)

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Article Engineering, Biomedical

Cancer stem cell labeling using poly(L-lysine)-modified iron oxide nanoparticles

Xueqin Wang et al.

BIOMATERIALS (2012)

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Review Neurosciences

The origin of extracellular fields and currents - EEG, ECoG, LFP and spikes

Gyoergy Buzsaki et al.

NATURE REVIEWS NEUROSCIENCE (2012)

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Article Neurosciences

Large-scale, high-resolution electrophysiological imaging of field potentials in brain slices with microelectronic multielectrode arrays

E. Ferrea et al.

FRONTIERS IN NEURAL CIRCUITS (2012)

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Article Cell & Tissue Engineering

Intranasal Delivery of Neural Stem/Progenitor Cells: A Noninvasive Passage to Target Intracerebral Glioma

Matthias Reitz et al.

STEM CELLS TRANSLATIONAL MEDICINE (2012)

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Article Neurosciences

Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: A potential model system to study neuroprotection

Tao Su et al.

BRAIN RESEARCH (2011)

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Article Cell Biology

Magnetic manipulation and spatial patterning of multi-cellular stem cell aggregates

Andres M. Bratt-Leal et al.

INTEGRATIVE BIOLOGY (2011)

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Review Nanoscience & Nanotechnology

Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues

Davide Brambilla et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

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Article Multidisciplinary Sciences

A synaptic organizing principle for cortical neuronal groups

Rodrigo Perin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Article Anatomy & Morphology

Analyses of neuronal damage in excitotoxically lesioned organotypic hippocampal slice cultures

Fahim Ebrahimi et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2010)

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Article Engineering, Biomedical

Generation and manipulation of magnetic multicellular spheroids

Vincent H. B. Ho et al.

BIOMATERIALS (2010)

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Article Neurosciences

Ultrastructural Analysis of Hippocampal Neuropil from the Connectomics Perspective

Yuriy Mishchenko et al.

NEURON (2010)

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Article Biophysics

Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices

U. Frey et al.

BIOSENSORS & BIOELECTRONICS (2009)

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Review Neurosciences

Stem Cell-Based Cell Therapy in Neurological Diseases: A Review

Seung U. Kim et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2009)

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Article Biochemical Research Methods

Micro-fluidic actuation using magnetic artificial cilia

Francis Fahrni et al.

LAB ON A CHIP (2009)

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Article Biochemical Research Methods

Poly(L-lysine)-modified iron oxide nanoparticles for stem cell labeling

Michal Babic et al.

BIOCONJUGATE CHEMISTRY (2008)

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Article Biochemical Research Methods

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

Ruei-Zhen Lin et al.

Biotechnology Journal (2008)

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Article Cell & Tissue Engineering

Magnetic reconstruction of three-dimensional tissues from multicellular spheroids

Ruei-Zeng Lin et al.

TISSUE ENGINEERING PART C-METHODS (2008)

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Article Biotechnology & Applied Microbiology

Microscale culture of human liver cells for drug development

Salman R. Khetani et al.

NATURE BIOTECHNOLOGY (2008)

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Article Engineering, Biomedical

Protein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potential

Swanand Patil et al.

BIOMATERIALS (2007)

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Article Neurosciences

Long-term rearrangements of hippocampal mossy fiber terminal connectivity in the adult regulated by experience

Ivan Galimberti et al.

NEURON (2006)

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Article Biochemical Research Methods

Preparation of organotypic hippocampal slice cultures for long-term live imaging

Nadine Gogolla et al.

NATURE PROTOCOLS (2006)

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Article Biochemical Research Methods

Preparation of organotypic hippocampal slice cultures: interface method

Anna De Simoni et al.

NATURE PROTOCOLS (2006)

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Article Neurosciences

Molecular determinants of synapsin targeting to presynaptic terminals

D Gitler et al.

JOURNAL OF NEUROSCIENCE (2004)

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Article Neurosciences

Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS

MD Dunning et al.

JOURNAL OF NEUROSCIENCE (2004)

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Article Engineering, Biomedical

Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks

J van Pelt et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2004)

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Article Neurosciences

AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks

V De Paola et al.

NATURE NEUROSCIENCE (2003)

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Article Physics, Fluids & Plasmas

Observations and modeling of synchronized bursting in two-dimensional neural networks

R Segev et al.

PHYSICAL REVIEW E (2001)

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A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice

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