期刊
JOURNAL OF NEUROGENETICS
卷 30, 期 2, 页码 133-148出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/01677063.2016.1180385
关键词
Behavior; dopamine; functional conservation; neuromodulators; neuropeptides; neurotransmitters
资金
- Richard and Susan Smith Family Foundation, Newton, MA
- Brown Institute for Brain Science
- Center for Nervous System Function
- COBRE Project Leader Award [NIGMS P20GM103645]
- Rhode Island Foundation Medical Research Award [20144133]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103645] Funding Source: NIH RePORTER
In a complex environment, animals learn from their responses to stimuli and events. Appropriate response to reward and punishment can promote survival, reproduction and increase evolutionary fitness. Interestingly, the neural processes underlying these responses are remarkably similar across phyla. In all species, dopamine is central to encoding reward and directing motivated behaviors, however, a comprehensive understanding of how circuits encode reward and direct motivated behaviors is still lacking. In part, this is a result of the sheer diversity of neurons, the heterogeneity of their responses and the complexity of neural circuits within which they are found. We argue that general features of reward circuitry are common across model organisms, and thus principles learned from invertebrate model organisms can inform research across species. In particular, we discuss circuit motifs that appear to be functionally equivalent from flies to primates. We argue that a comparative approach to studying and understanding reward circuit function provides a more comprehensive understanding of reward circuitry, and informs disorders that affect the brain's reward circuitry.
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