期刊
ADVANCED FUNCTIONAL MATERIALS
卷 33, 期 8, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202211277
关键词
biocatalytic precipitation; biomolecules; metal-organic frameworks; organic electrochemical transistor; photoelectrochemical transistors
Biomolecules-incorporated MOFs have been used as innovative gating modules for organic devices, demonstrating a variant gating effect based on sensitive responses. This study provides a proof-of-concept for the development of biomolecules-MOFs-gated electronics.
Incorporating biomolecules into metal-organic frameworks (MOFs) as exoskeletons to form biomolecules-MOFs biohybrids has attracted great attention as an emerging class of advanced materials. Organic devices have been shown as powerful platforms for next-generation bioelectronics, such as wearable biosensors, tissue engineering constructs, and neural interfaces. Herein, biomolecules-incorporated MOFs as innovative gating module is realized for the first time, which is exemplified by biocatalytic precipitation (BCP)-oriented horseradish peroxidase (HRP)-embedded zeolitic imidazolate framework-90 (HRP@ZIF-90)/CdIn2S4 gated organic photoelectrochemical transistor under light illumination. In connection to a sandwich immunocomplexing targeting the model analyte human IgG, the IgG-dependent generation of H2O2 and the tandem HRP-triggered BCP reaction can cause the in situ blocking of the pore network of ZIF-90, leading to variant gating effect with corresponding responses of the device. This representative biodetection achieved good analytical performance with a wide linear range and a low detection limit of 100 fg mL(-1). In the view of the plentiful biomolecule-MOF complexes and their potential interactions with organic systems, this study provides a proof-of-concept study for the generic development of biomolecules-MOFs-gated electronics and beyond.
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