A Multifunctional Coating Strategy for Promotion of Immunomodulatory and Osteo/Angio-Genic Activity

Building of multifunctional coatings in a more effective way is crucial for meeting the multilevel requirements of regenerative medicine. Herein, inspired by diatom and mussel, a specific but universal approach is proposed for building multifunctional coatings on slow-degradable and fast-degradable scaffolds or various substrates by using epigallocatechin gallate (EGCG) and polyethyleneimine (PEI) as bridges of silicon coupling. The results reveal that the polyphenol EGCG facilitates silica precipitation and coating topological morphology in synergy with PEI, and realizes antioxidant and immunomodulatory effects. The introduction of EGCG and the release of silicon ions present effective modulation of the immune microenvironment and remarkable promotion of angiogenesis and osteogenesis. The EGCG/silica coating strategy demonstrates a promising perspective for designing multifunctional coatings and optimizing tissue regeneration and reconstruction.

Automated summary

A specific but universal approach is proposed for building multifunctional coatings on different degradable scaffolds and substrates by using EGCG and PEI as bridges. The results show that the combination of EGCG and PEI facilitates silica precipitation and coating topological morphology, and achieves antioxidant and immunomodulatory effects, leading to effective modulation of the immune microenvironment and significant promotion of angiogenesis and osteogenesis. The EGCG/silica coating strategy demonstrates a promising potential for designing multifunctional coatings and optimizing tissue regeneration and reconstruction.