期刊
JOURNAL OF NEUROENDOCRINOLOGY
卷 28, 期 4, 页码 -出版社
WILEY
DOI: 10.1111/jne.12347
关键词
oxytocin; nociception; analgesia; laser-evoked potentials; EEG
资金
- Economic and Social Research Council fellowship [ES/K009400/1]
- Volkswagen Foundation 'European Platform for Life Sciences, Mind Sciences and Humanities' [II/85 069]
- Institute for the Study of Affective Neuroscience (ISAN)/Hope for Depression Research Foundation (HDRF)
- European Research Council Starting Investigator Award' [ERC-2012-STG GA313755]
- Medical Research Council Developmental Pathway Funding Scheme award [MR/J005142/1]
- NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Trust
- Economic and Social Research Council [ES/K009400/1] Funding Source: researchfish
- Medical Research Council [MR/J005142/1] Funding Source: researchfish
- ESRC [ES/K009400/1] Funding Source: UKRI
- MRC [MR/J005142/1] Funding Source: UKRI
Oxytocin is a neuropeptide regulating social-affiliative and reproductive behaviour in mammals. Despite robust preclinical evidence for the antinociceptive effects and mechanisms of action of exogenous oxytocin, human studies have produced mixed results regarding the analgesic role of oxytocin and are yet to show a specific modulation of neural processes involved in pain perception. In the present study, we investigated the analgesic effects of 40IU of intranasal oxytocin in 13 healthy male volunteers using a double-blind, placebo-controlled, cross-over design and brief radiant heat pulses generated by an infrared laser that selectively activate A- and C-fibre nerve endings in the epidermis, at the same time as recording the ensuing laser-evoked potentials (LEPs). We predicted that oxytocin would reduce subjective pain ratings and attenuate the amplitude of the N1, N2 and P2 components. We observed that oxytocin attenuated perceived pain intensity and the local peak amplitude of the N1 and N2 (but not of P2) LEPs, and increased the latency of the N2 component. Importantly, for the first time, the present study reports an association between the analgesic effect of oxytocin (reduction in subjective pain ratings) and the oxytocin-induced modulation of cortical activity after noxious stimulation (attenuation of the N2 LEP). These effects indicate that oxytocin modulates neural processes contributing to pain perception. The present study reports preliminary evidence that is consistent with electrophysiological studies in rodents showing that oxytocin specifically modulates A/C-fibre nociceptive afferent signalling at the spinal level and provides further specificity to evidence obtained in humans indicating that oxytocin may be modulating pain experience by modulating activity in the cortical areas involved in pain processing.
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