期刊
JOURNAL OF NEUROCHEMISTRY
卷 138, 期 2, 页码 204-221出版社
WILEY
DOI: 10.1111/jnc.13658
关键词
adult hippocampal neurogenesis; BDNF isoforms; rodents; serotonergic system; SSRI antidepressants
资金
- Committee for Aid and Education in Neurochemistry of the International Society of Neurochemistry (CAEN-ISN)
- Argentine Agency for Promotion of Science and Technology [PICT 2013-3225]
- University of Moron [PID2-2015]
- Argentine Medical Research Council (CONICET) [PIP-11220130100157CO]
- CONICET
The brain-derived neurotrophic factor, BDNF, was discovered more than 30years ago and, like other members of the neurotrophin family, this neuropeptide is synthetized as a proneurotrophin, the pro-BDNF, which is further cleaved to yield mature BDNF. The myriad of actions of these two BDNF isoforms in the central nervous system is constantly increasing and requires the development of sophisticated tools and animal models to refine our understanding. This review is focused on BDNF isoforms, their participation in the process of neurogenesis taking place in the hippocampus of adult mammals, and the modulation of their expression by serotonergic agents. Interestingly, around this triumvirate of BDNF, serotonin, and neurogenesis, a series of recent research has emerged with apparently counterintuitive results. This calls for an exhaustive analysis of the data published so far and encourages thorough work in the quest for new hypotheses in the field.
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