4.6 Article

LATE-NC staging in routine neuropathologic diagnosis: an update

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC

Michel J. Grothe et al.

Summary: This study investigated the clinical utility of an autopsy-derived FDG-PET signature for differential diagnosis of amnestic dementia patients. The study found that an FDG-PET pattern resembling LATE-NC can identify older patients with clinical features consistent with underlying LATE-NC. These patients exhibit a memory-predominant profile and a slower disease course.

ALZHEIMERS & DEMENTIA (2023)

Article Clinical Neurology

Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease

Maiko T. Uemura et al.

Summary: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by the accumulation of TAR-DNA-binding protein 43 (TDP-43) aggregates in older adults and coexists with Lewy body disease (LBD) and Alzheimer's disease (AD). Pathological and genetic characteristics of LATE in LBD (LATE-LBD) differ from LATE-AD, with associations to patient profiles and cognitive impairment. The distribution of LATE neuropathological changes and genetic risk factors also vary between LATE-LBD and LATE-AD.

ACTA NEUROPATHOLOGICA (2022)

Review Neurosciences

Glial TDP-43 and TDP-43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes

Katherine E. Prater et al.

Summary: Since its discovery in 2006, TDP-43 has been a key focus in research on neurodegenerative diseases, contributing to cognitive impairment and potentially potentiating other proteinopathies. However, there are still gaps in understanding TDP-43 driven mechanisms across different cell types, and further research is needed on the relationship between TDP-43 and glial pathology.
Article Clinical Neurology

An immigrant family with Kii amyotrophic lateral sclerosis/parkinsonism-dementia complex

Yasumasa Kokubo et al.

Summary: This study reports an immigrant family from outside the Kii Peninsula where the father developed ALS 18 years after immigration and the daughter developed ALS 65 years after immigration, showing pure ALS phenotype. Neuropathological diagnosis of the daughter revealed multiple proteinopathies, suggesting environmental factors play a critical role in the pathogenesis of Kii ALS/PDC.

NEUROLOGICAL SCIENCES (2022)

Article Clinical Neurology

Limbic-Predominant Age-Related TDP-43 Encephalopathy Medical and Pathologic Factors Associated With Comorbid Hippocampal Sclerosis

Kathryn M. Gauthreaux et al.

Summary: Limbic-predominant age-related Tar DNA binding protein 43 (TDP-43) encephalopathy neuropathologic change (LATE-NC) is strongly associated with cognitive impairment. This study found that LATE-NC patients with hippocampal sclerosis (HS) pathology may have worse cognitive status and more severe impairments in memory and orientation. Additionally, the presence of comorbid HS pathology is associated with more widespread TDP-43 proteinopathy and more severe non-beta-amyloid vessel wall pathologies.

NEUROLOGY (2022)

Article Neuroimaging

TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration

Marina Buciuc et al.

Summary: The study found differences and similarities in longitudinal brain volume loss between FTLD-TDP and non-FTLD TDP-43, with faster atrophy rates in certain brain regions for FTLD-TDP and faster hippocampal atrophy rates in AD-TDP type-a.

NEUROIMAGE-CLINICAL (2022)

Article Neurosciences

Developmental deficits and staging of dynamics of age associated Alzheimer's disease neurodegeneration and neuronal loss in subjects with Down syndrome

Jerzy Wegiel et al.

Summary: This study examined the brain regions of individuals with Down syndrome (DS) and found that intellectual deficits were associated with developmental neuronal deficits and AD-related neuronal loss. Age and stage of dementia were strong predictors of AD-associated decrease of neurons. The findings suggest that treating DS individuals in their forties may prevent AD pathology and functional decline.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)

Article Clinical Neurology

Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old

Shih-Hsiu J. Wang et al.

Summary: LATE-NC is most common in the oldest-old population but can also occur in the younger-old. The prevalence and associations differ in these two age groups, with LATE-NC often co-occurring with hippocampal sclerosis and arteriolosclerosis in the oldest-old, while being associated with Alzheimer's disease neuropathologic change and Lewy body disease in addition to hippocampal sclerosis and arteriolosclerosis in the younger-old.

ACTA NEUROPATHOLOGICA (2022)

Article Clinical Neurology

Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies

Matthew D. Cykowski et al.

Summary: LATE-NC in the amygdala region exhibits different patterns of initiation, but also shares genetic risk and convergent pathways of clinico-pathological evolution.

ACTA NEUROPATHOLOGICA (2022)

Article Clinical Neurology

Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration

Yuichi Riku et al.

Summary: Mislocalization and cytoplasmic aggregation of TDP-43 in spinal cord motor neurons have been found in various neurological disorders, suggesting mechanistic links. Additionally, the severity of TDP-43 pathology in the spinal cord correlates with the severity of 4R-tau aggregates. These findings provide insights into the pathology and potential mechanisms underlying TDP-43-related diseases.
Article Clinical Neurology

DNAJB2-related Charcot-Marie-Tooth disease type 2: Pathomechanism insights and phenotypic spectrum widening

Paola Saveri et al.

Summary: We describe a family with CMT2 caused by a homozygous DNAJB2 mutation and provide insights into the pathomechanisms. The mutation leads to severe muscle weakness, loss of movement, and reduced sensation in the lower limbs. Patients also exhibit severe hearing loss and one patient has Parkinson's disease. The study reveals reduced levels of DNAJB2 mRNA and protein, as well as the presence of phospho-alpha-synuclein deposits and TDP-43 accumulation in the patients.

EUROPEAN JOURNAL OF NEUROLOGY (2022)

Article Neurosciences

Patterns of Mixed Pathologies in Down Syndrome

Shojiro Ichimata et al.

Summary: This study evaluated multiple disease-associated proteinopathies in a series of Down syndrome (DS) cases. The findings showed that DS patients exhibit distinct features in the spectrum of mixed-pathologies, including deviations from classical AD pathology and the presence of Lewy-related pathology, LATE neuropathologic change, and ARTAG pathology. These observations suggest that DS has distinctive pathogenic pathways from sporadic AD.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Article Clinical Neurology

Parallel Appearance of Polyglutamine and Transactivation-Responsive DNA-Binding Protein 43 and Their Complementary Subcellular Localization in Brains of Patients With Spinocerebellar Ataxia Type 2

Shigeru Koyano et al.

Summary: SCA2 is a genetic disorder caused by mutations in the ATXN2 gene, resulting in toxic effects triggered by expanded polyglutamine repeats in ataxin-2. This study investigated the distribution patterns of ataxin-2 and TDP-43 in the CNS of SCA2 patients. It was found that pTDP-43-positive lesions were widely distributed throughout the CNS and overlapped with expanded polyglutamine immunoreactive lesions. The study also revealed different staining patterns of TDP-43 and 1C2 in motor neurons, reflecting different stages of pathological change. The findings suggest a close interrelationship between mutant ataxin-2 and TDP-43 in SCA2.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2022)

Letter Clinical Neurology

TDP-43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease

Rika Yamashita et al.

MOVEMENT DISORDERS (2022)

Article Geriatrics & Gerontology

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate: an ex-vivo MRI and pathology investigation

Mahir Tazwar et al.

Summary: This study found an association between limbic predominant age-related transactive response DNA binding protein 43 (TDP-43) encephalopathy neuropathological change (LATE-NC) and the transverse relaxation rate R-2. R-2 imaging can capture the progression of LATE-NC, and the spatial pattern of lower R-2 is consistent with the distribution of LATE-NC in the brain.

NEUROBIOLOGY OF AGING (2022)

Article Clinical Neurology

A novel missense HNRNPA1 variant in the PY-NLS domain in a patient with late-onset distal myopathy

Pitcha Chompoopong et al.

Summary: In this study, a novel variant in the HNRNPA1 gene was identified in a male patient with bilateral foot drop, expanding the phenotypic spectrum of hnRNPA1opathy.

NEUROMUSCULAR DISORDERS (2022)

Article Medicine, General & Internal

Association of Traumatic Brain Injury With and Without Loss of Consciousness With Neuropathologic Outcomes in Community-Dwelling Older Persons

Sonal Agrawal et al.

Summary: This cross-sectional analysis suggests that a history of traumatic brain injury, even without loss of consciousness, is associated with age-related neuropathologic outcomes, including neurodegenerative and vascular pathologies. These findings are significant for understanding the mechanisms, diagnosis, and management of individuals with traumatic brain injury.

JAMA NETWORK OPEN (2022)

Article Clinical Neurology

Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts

Peter T. Nelson et al.

Summary: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) and Alzheimer's disease neuropathologic change (ADNC) are both associated with cognitive impairment in aging populations, with LATE-NC being present in approximately 40% of participants and more commonly in cases with poorer cognitive abilities.

ACTA NEUROPATHOLOGICA (2022)

Article Clinical Neurology

TDP-43 Pathology Exacerbates Cognitive Decline in Primary Age-Related Tauopathy

Denis S. Smirnov et al.

Summary: This study compares the prevalence of LATE-NC and vascular copathologies in patients with PART and early stage ADNC, and examines their influence on clinical and cognitive decline. The study found that both LATE-NC and vascular pathology are common in PART and ADNC patients, and they exacerbate cognitive impairment and decline.

ANNALS OF NEUROLOGY (2022)

Article Clinical Neurology

Old age amyotrophic lateral sclerosis and limbic TDP-43 pathology

Aya Murakami et al.

Summary: This study aimed to assess and compare the burden of transactive response DNA-binding protein of 43 kDa (TDP-43) pathology and clinical features of amyotrophic lateral sclerosis (ALS) in three age groups. The study found that the amygdala and hippocampus are vulnerable to TDP-43 pathology in older patients with ALS.

BRAIN PATHOLOGY (2022)

Article Geriatrics & Gerontology

Cognitive resilience to three dementia-related neuropathologies in an oldest-old man: A case report from The 90+Study

Zarui A. Melikyan et al.

Summary: This study describes a participant of The 90+ Study who maintained normal cognition despite having multiple dementia-related neuropathologic changes, advanced age, and comorbidities. It demonstrates that cognitive impairment is not inevitable even in the oldest-old with various neuropathologic changes.

NEUROBIOLOGY OF AGING (2022)

Article Clinical Neurology

Association of Cognition and Dementia With Neuropathologic Changes of Alzheimer Disease and Other Conditions in the Oldest Old

Thomas J. Montine et al.

Summary: This study aims to describe neuropathologic lesions in the oldest-old individuals and their associations with antemortem cognition. The results show that non-Alzheimer disease neuropathologic comorbidity, especially limbic-predominant age-related TDP-43 encephalopathy, has a significant impact on cognition. Reducing the prevalence of non-Alzheimer disease comorbidities, especially limbic-predominant age-related TDP-43 encephalopathy, is crucial for reducing the burden of dementia in the oldest-old individuals.

NEUROLOGY (2022)

Article Neurosciences

Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old

Christian Lachner et al.

Summary: In the oldest-old population, there is a relationship between diabetes, coronary artery disease, cancer, and the occurrence of dementia. Diabetes is associated with an increase in cerebrovascular pathology, while cancer is associated with a decrease in dementia occurrence and tangle pathology.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Article Geriatrics & Gerontology

Association of glial tau pathology and LATE-NC in the ageing brain

Shelley L. Forrest et al.

Summary: This study investigated a wide range of brain pathologies in an unselected European community-dwelling ageing cohort, revealing the presence of various pathologies such as neurofibrillary tangles, ARTAG, and corpora amylacea. The study identified an association between LATE-NC and ARTOG, emphasizing common pathogenic aspects among different ARTAG types. Additionally, only neurofibrillary tangles and LATE-NC were found to be associated with cognitive decline.

NEUROBIOLOGY OF AGING (2022)

Article Neurosciences

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer's disease

Marta J. Koper et al.

Summary: Alzheimer's Disease (AD) is not only linked to its hallmark lesions, but also to other co-occurring pathologies. The presence of phosphorylated transactive-response DNA binding protein 43 (pTDP-43) and granulovacuolar degeneration (GVD) are co-pathologies associated with AD. This study investigated the impact of LATE-NC on the severity of necroptosis-associated GVD lesions, phosphorylated tau (pTau) pathology, and neuronal density. The results suggest that the presence of LATE-NC in AD contributes to necroptosis pathway activation, leading to an accelerated neuronal demise.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)

Review Clinical Neurology

Brain arteriolosclerosis

Brittney L. Blevins et al.

Summary: Brain arteriolosclerosis (B-ASC) is a common finding at autopsy in aged individuals, associated with cognitive impairment, hypertension, and diabetes, and possibly other complex risk factors and pathogenetic mechanisms. It is a complex and under-studied contributor to neurologic disability, with potential interactions between metabolic syndrome and brain arteriolar pathology.

ACTA NEUROPATHOLOGICA (2021)

Article Geriatrics & Gerontology

Underlying genetic variation in familial frontotemporal dementia: sequencing of 198 patients

Merel O. Mol et al.

Summary: The study found a significant proportion of pathogenic or likely pathogenic genetic variants in FTD patients, including some newly discovered variants. Common variant genes include C9orf72, MAPT, GRN, and TARDBP, while other pathogenic variants were found in VCP, TBK1, PSEN1, etc. Patients without identified genetic cause showed a wide range of clinical and pathological variability.

NEUROBIOLOGY OF AGING (2021)

Article Clinical Neurology

Necrosome-positive granulovacuolar degeneration is associated with TDP-43 pathological lesions in the hippocampus of ALS/FTLD cases

E. Van Schoor et al.

Summary: The presence of necrosome-positive GVD in ALS/FTLD patients was primarily linked to hippocampal TDP-43 pathology, while motor neuron loss in ALS showed no accumulation of necroptosis-related proteins.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2021)

Article Clinical Neurology

Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study

Johannes Attems et al.

Summary: Several staging systems exist for the neuropathological diagnosis of LBD, with varying levels of inter-rater reliability. The LPC system, based on a dichotomous approach for scoring LP, showed good reproducibility and allowed for the classification of all cases into distinct categories. It may serve as a reliable and useful standard future approach for the post-mortem evaluation of LP.

ACTA NEUROPATHOLOGICA (2021)

Article Neurosciences

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer's disease brain

Hans-Ulrich Klein et al.

Summary: This study found lower mtDNAcn in AD patients compared to controls, with tau pathology primarily associated with reduced mtDNAcn. In the posterior cingulate cortex, TDP-43 pathology was distinctly linked to low mtDNAcn. Mitochondrial content and mtDNAcn independently affected cognitive function, while mtDNA heteroplasmy levels showed no association with pathology or cognition.

MOLECULAR NEURODEGENERATION (2021)

Letter Clinical Neurology

First Japanese autopsy case showing LRRK2 mutation G2019S and TDP-43 proteinopathy

Mayuko Sakuwa et al.

Summary: This study reports the first Japanese autopsy case of Leucine-rich repeat kinase 2 (LRRK2) G2019S mutation with atypical TDP43 proteinopathy, suggesting that TDP43 protein may play an important role in the clinical presentation of individuals carrying the LRRK2 G2019S mutation.

PARKINSONISM & RELATED DISORDERS (2021)

Article Clinical Neurology

To what degree is late life cognitive decline driven by age-related neuropathologies?

Patricia A. Boyle et al.

Summary: The study found that cognitive decline in old age is driven by a wide array of neuropathologies, with Alzheimer's disease, infarcts, non-Alzheimer's disease neurodegenerative diseases, and cerebrovascular conditions playing significant roles. While most pathological indices were associated with faster decline, they only accounted for a portion of the variation in decline, highlighting the complexity of cognitive ageing.
Article Neurosciences

The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer's dementia in older persons

Sonal Agrawal et al.

Summary: LBs and LATE-NC are common in older individuals and linked to cognitive impairment. The combination of LBs and LATE-NC may affect cognition and Alzheimer's dementia in community-dwelling participants. Neocortical-type LBs are associated with LATE-NC, particularly in younger old individuals and women, and have separate and additive effects on cognitive function and odds of Alzheimer's dementia.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Article Clinical Neurology

Old age genetically confirmed frontotemporal lobar degeneration with TDP-43 has limbic predominant TDP-43 deposition

Marina Buciuc et al.

Summary: The burden of TDP-43 inclusions was assessed in elderly patients with genetic FTLD-TDP and compared to sporadic cases with TDP-43. It was found that patients with genetic FTLD-TDP had a higher burden in the entorhinal cortex compared to AD-TDP, but no significant difference in the middle frontal cortex burden.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2021)

Article Clinical Neurology

The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample

Nadia Postupna et al.

Summary: This study conducted a multimodal neuropathological investigation on 532 consecutive brain autopsies, revealing that only a small minority showed neuropathological features of chronic traumatic encephalopathy. While cases with TBI w/LOC history had higher levels of hippocampal pTau, overall, long-term neuropathological changes associated with TBI exposure may not be significant.

FRONTIERS IN NEUROLOGY (2021)

Article Neurosciences

Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study

Adam J. Dugan et al.

Summary: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is one of the most common subtypes of TDP-43 proteinopathy, often co-occurring with hippocampal sclerosis (HS) pathology, and showing associations with specific genetic variants. Through analyzing the genetic associations with HS, LATE-NC, and Alzheimer's pathologies, significant gene-based associations were found, offering new insights into the differential effects of risk alleles on LATE-NC and HS.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Article Clinical Neurology

The development and convergence of co-pathologies in Alzheimer's disease

John L. Robinson et al.

Summary: This study found that CAA, LATE-NC, and Lewy bodies are common pathologies in Alzheimer's disease that worsen in severity as the disease progresses. Age was associated with all pathologies, while the APOE epsilon 4 gene was specifically linked to CAA. In individuals with dementia, age was linked to LATE-NC, while Lewy bodies were more common in younger patients.
Article Clinical Neurology

Myositis with sarcoplasmic inclusions in Nakajo-Nishimura syndrome: a genetic inflammatory myopathy

T. Ayaki et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2020)

Review Neurosciences

TDP-43: From Alzheimer's Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy

Wendi Huang et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Article Neurosciences

Distinct molecular patterns of TDP-43 pathology in Alzheimer's disease: relationship with clinical phenotypes

Sandra O. Tome et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)

Article Clinical Neurology

Hippocampal sclerosis, TDP-43, and the duration of the symptoms of dementia of AD patients

Oscar L. Lopez et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2020)

Article Clinical Neurology

Concomitant LATE-NC in Alzheimer's disease is not associated with increased tau or amyloid-β pathological burden

K. E. McAleese et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2020)

Article Clinical Neurology

FOSMN A possible TDP-43 proteinopathy to consider in a patient with facial sensory symptoms

Garazi Agirre-Beitia et al.

NEUROLOGY-CLINICAL PRACTICE (2020)

Article Medicine, General & Internal

An Autopsy-Proven Case of Limbic-Predominant Age-Related TDP-43 Encephalopathy

Soo Hyun Cho et al.

YONSEI MEDICAL JOURNAL (2020)

Review Medicine, Research & Experimental

Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy

Yevgen Chornenkyy et al.

LABORATORY INVESTIGATION (2019)

Letter Clinical Neurology

Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes

Yasushi Nishihira et al.

ACTA NEUROPATHOLOGICA (2019)

Letter Clinical Neurology

LATE to the PART-y

Keith A. Josephs et al.

Letter Clinical Neurology

Reply: LATE to the PART-y

Peter T. Nelson et al.

Article Clinical Neurology

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies

Patricia A. Boyle et al.

ANNALS OF NEUROLOGY (2019)

Article Neurosciences

Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy

Xiaoling Zhang et al.

NEUROSCIENCE BULLETIN (2019)

Review Clinical Neurology

The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

Peter T. Nelson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2018)

Editorial Material Clinical Neurology

Integrated neurodegenerative disease autopsy diagnosis

Edward B. Lee

ACTA NEUROPATHOLOGICA (2018)

Article Clinical Neurology

Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+Study

John L. Robinson et al.

ACTA NEUROPATHOLOGICA (2018)

Article Clinical Neurology

Combined neuropathological pathways account for age-related risk of dementia

Melinda C. Power et al.

ANNALS OF NEUROLOGY (2018)

Review Clinical Neurology

Genotype-phenotype links in frontotemporal lobar degeneration

Sara Van Mossevelde et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Neurosciences

TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer's disease

Sukriti Nag et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

Article Clinical Neurology

Relative neuron loss in hippocampal sclerosis of aging and Alzheimer's disease

Ryoko Ihara et al.

ANNALS OF NEUROLOGY (2018)

Article Neurosciences

TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study

Margaret E. Flanagan et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Clinical Neurology

Risk factors of hippocampal sclerosis in the oldest old The 90+Study

Thomas Trieu et al.

NEUROLOGY (2018)

Article Clinical Neurology

Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population

Suvi R. K. Hokkanen et al.

BRAIN PATHOLOGY (2018)

Review Neurosciences

Challenges and Considerations Related to Studying Dementia in Blacks/African Americans

Eseosa T. Ighodaro et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

Article Clinical Neurology

Reappraisal of TDP-43 pathology in FTLD-U subtypes

Ian R. Mackenzie et al.

ACTA NEUROPATHOLOGICA (2017)

Article Clinical Neurology

Updated TDP-43 in Alzheimer's disease staging scheme

Keith A. Josephs et al.

ACTA NEUROPATHOLOGICA (2016)

Article Clinical Neurology

TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia

Bryan D. James et al.

Letter Clinical Neurology

THE TMEM106B LOCUS AND TDP-43 PATHOLOGY IN OLDER PERSONS WITHOUT FTLD

Dennis W. Dickson et al.

NEUROLOGY (2015)

Review Neurosciences

TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

Joery Goossens et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)

Article Neurosciences

Incidence and extent of TDP-43 accumulation in aging human brain

Akiko Uchino et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)

Review Clinical Neurology

The neuropathology associated with repeat expansions in the C9ORF72 gene

Ian R. A. Mackenzie et al.

ACTA NEUROPATHOLOGICA (2014)

Article Clinical Neurology

Staging TDP-43 pathology in Alzheimer's disease

Keith A. Josephs et al.

ACTA NEUROPATHOLOGICA (2014)

Article Clinical Neurology

Differential clinicopathologic and genetic features of late-onset amnestic dementias

Melissa E. Murray et al.

ACTA NEUROPATHOLOGICA (2014)

Article Clinical Neurology

TDP-43 is a key player in the clinical features associated with Alzheimer's disease

Keith A. Josephs et al.

ACTA NEUROPATHOLOGICA (2014)

Article Neurosciences

TDP-43 Pathology in the Population: Prevalence and Associations with Dementia and Age

Hannah A. D. Keage et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Article Neurosciences

Astrocytic TDP-43 Pathology in Alexander Disease

Adam K. Walker et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Ophthalmology

Unique Hard Scleral Lens Post-LASIK Ectasia Fitting

Rajeswari Mahadevan et al.

OPTOMETRY AND VISION SCIENCE (2014)

Article Neurosciences

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins

Linda K. Kwong et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2014)

Article Clinical Neurology

Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72

Melissa E. Murray et al.

ACTA NEUROPATHOLOGICA (2013)

Review Clinical Neurology

Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

Peter T. Nelson et al.

ACTA NEUROPATHOLOGICA (2013)

Article Clinical Neurology

Stages of pTDP-43 Pathology in Amyotrophic Lateral Sclerosis

Johannes Brettschneider et al.

ANNALS OF NEUROLOGY (2013)

Article Clinical Neurology

Pathology of clinical and preclinical Alzheimer's disease

Dietmar Rudolf Thal et al.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2013)

Review Clinical Neurology

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Peter T. Nelson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2012)

Article Behavioral Sciences

Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample

Chris Zarow et al.

BRAIN AND BEHAVIOR (2012)

Article Clinical Neurology

Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response

Dietmar Rudolf Thal et al.

ACTA NEUROPATHOLOGICA (2011)

Letter Clinical Neurology

A harmonized classification system for FTLD-TDP pathology

Ian R. A. Mackenzie et al.

ACTA NEUROPATHOLOGICA (2011)

Article Clinical Neurology

Hippocampal Sclerosis in the Elderly Genetic and Pathologic Findings, Some Mimicking Alzheimer Disease Clinically

Winnie C. Pao et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2011)

Article Clinical Neurology

Hippocampal sclerosis in advanced age: clinical and pathological features

Peter T. Nelson et al.

Editorial Material Clinical Neurology

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

Ian R. A. Mackenzie et al.

ACTA NEUROPATHOLOGICA (2010)

Article Clinical Neurology

TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

Ann C. McKee et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)

Editorial Material Clinical Neurology

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

Ian R. A. Mackenzie et al.

ACTA NEUROPATHOLOGICA (2009)

Article Clinical Neurology

Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes

Keith A. Josephs et al.

ACTA NEUROPATHOLOGICA (2009)

Article Clinical Neurology

Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies

Tetsuaki Arai et al.

ACTA NEUROPATHOLOGICA (2009)

Article Clinical Neurology

Hippocampal Sclerosis: Progress Since Sommer

Maria Thom

BRAIN PATHOLOGY (2009)

Article Clinical Neurology

Transactivation Response DNA-Binding Protein 43 Microvasculopathy in Frontotemporal Degeneration and Familial Lewy Body Disease

Wen-Lang Lin et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)

Article Clinical Neurology

Pallidonigral TDP-43 pathology in Perry syndrome

Christian Wider et al.

PARKINSONISM & RELATED DISORDERS (2009)

Article Clinical Neurology

Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease

William T. Hu et al.

ACTA NEUROPATHOLOGICA (2008)

Article Clinical Neurology

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Masato Hasegawa et al.

ANNALS OF NEUROLOGY (2008)

Review Clinical Neurology

Understanding hippocampal sclerosis in the elderly: Epidemiology, characterization, and diagnostic issues

Chris Zarow et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2008)

Article Clinical Neurology

Concomitant TAR-DNA-binding in Alzheimer disease and protein 43 pathology is present corticobasal degeneration but not in other tauopathies

Kunihiro Uryu et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

Article Clinical Neurology

TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system

Edward B. Lee et al.

ACTA NEUROPATHOLOGICA (2008)

Review Clinical Neurology

TDP-43 in differential diagnosis of motor neuron disorders

Dennis W. Dickson et al.

ACTA NEUROPATHOLOGICA (2007)

Article Clinical Neurology

TDP-43 is deposited in the Guam parkinsonism-dementia complex brains

Masato Hasegawa et al.

Article Clinical Neurology

TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

Catalina Amador-Ortiz et al.

ANNALS OF NEUROLOGY (2007)

Article Clinical Neurology

Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration

Catalina Amador-Ortiz et al.

ACTA NEUROPATHOLOGICA (2007)

Article Multidisciplinary Sciences

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Manuela Neumann et al.

SCIENCE (2006)

Review Cell Biology

Stages in the development of Parkinson's disease-related pathology

H Braak et al.

CELL AND TISSUE RESEARCH (2004)