4.6 Article

RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer's Disease

Mehmet Ilyas Cosacak et al.

Summary: The research compared AD-related molecular pathways between humans and zebrafish, with 95.4% of cells co-clustering. Zebrafish can be used as a tool to study neurogenesis, and its uniquely altered pathways may contribute to the development of potential therapeutics.
Article Neurosciences

tRNA-Derived Fragments in Alzheimer's Disease: Implications for New Disease Biomarkers and Neuropathological Mechanisms

Wenzhe Wu et al.

Summary: This study found that certain tRFs are significantly altered in the hippocampus of AD patients, suggesting their involvement in the development of AD. The expression changes of some tRFs were age- and disease stage-dependent, and the study also indicated a potential role of ANG and NSun2 in the dysregulation of tRFs in AD.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Neurosciences

Molecular characterization of selectively vulnerable neurons in Alzheimer's disease

Kun Leng et al.

Summary: The study reveals the molecular signature of neuronal subpopulations vulnerable to tau aggregation and death in Alzheimer's disease, validating RORB as a marker. Using single-nucleus RNA sequencing, the research identified and characterized vulnerable neurons in the entorhinal cortex, as well as a subpopulation of astrocytes likely representing reactive astrocytes.

NATURE NEUROSCIENCE (2021)

Article Neurosciences

METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events

Fanpeng Zhao et al.

Summary: The study revealed that decreased m(6)A levels and reduced expression of METTL3 in AD brains led to memory deficits, synaptic loss, neuronal death, and multiple cellular alterations. Restoring m(6)A modification by inhibiting demethylation or overexpressing METTL3 rescued synaptic damage, cognitive impairment, and neuronal deficits in AD models.

MOLECULAR NEURODEGENERATION (2021)

Article Neurosciences

Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons

Derek H. Oakley et al.

Summary: This study established an accelerated human neuronal model incorporating soluble tau species and tau aggregation, and showed that uptake of exogenous tau seeds increases the risk of neuronal death. Specific morphologic strains of Tau aggregation were identified to be associated with differing levels of neurotoxicity. Additionally, iPSC neurons expressing the PSEN1 L435F mutation exhibited accelerated Tau aggregation kinetics and a bias in tau strain propagation.

JOURNAL OF NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy

Lulu Jiang et al.

Summary: The study found that oTau-c induces tau phosphorylation, aggregation, and a translational stress response, and identified HNRNPA2B1 as a principle target of oTau-c. HNRNPA2B1 functions as a linker connecting oTau with N6-methyladenosine (m6A) modified RNA transcripts.

MOLECULAR CELL (2021)

Review Neurosciences

Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery

Bing Bai et al.

Summary: Mass spectrometry-based proteomics plays a crucial role in Alzheimer's disease research, allowing for in-depth analysis of proteome and protein post-translational modifications. Studies have revealed not only known amyloid and tau pathways, but also novel protein networks in AD. Meta-analysis of deep datasets has identified a large number of differentially expressed proteins in the AD brain proteome, indicating the involvement of diverse cell types in Alzheimer's pathology.

MOLECULAR NEURODEGENERATION (2021)

Article Multidisciplinary Sciences

Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior

J. Blaze et al.

Summary: The deficiency of neuronal Nsun2 leads to codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice. Disruption of neuronal tRNA cytosine methylation results in bi-directional changes in depression-related behaviors and alterations in the neuronal translatome. These findings highlight the importance of methylation sensitivity of glycinergic tRNAs in the adult prefrontal cortex and the link between synaptic plasticity and complex behaviors to epitranscriptomic modifications of cognate tRNAs and specific amino acids in the proteomic homeostasis.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Modeling Alzheimer's disease with iPSC-derived brain cells

Jay Penney et al.

MOLECULAR PSYCHIATRY (2020)

Review Chemistry, Multidisciplinary

Angiogenin and tRNA fragments in Parkinson's disease and neurodegeneration

Jochen H. M. Prehn et al.

ACTA PHARMACOLOGICA SINICA (2020)

Article Neurosciences

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer's Disease

Min Han et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Cell Biology

The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer

Anitha Chellamuthu et al.

Article Biochemistry & Molecular Biology

On the expanding roles of tRNA fragments in modulating cell behavior

Rogan Magee et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Biochemistry & Molecular Biology

New Insights on the Role ofN6-Methyladenosine RNA Methylation in the Physiology and Pathology of the Nervous System

Georgia Dermentzaki et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Article Biochemistry & Molecular Biology

Genome-wide identification of mRNA 5-methylcytosine in mammals

Tao Huang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Article Clinical Neurology

TRNA-derived fragments as sex-dependent circulating candidate biomarkers for Parkinson's disease

Rogan Magee et al.

PARKINSONISM & RELATED DISORDERS (2019)

Article Multidisciplinary Sciences

Distinct methylation levels of mature microRNAs in gastrointestinal cancers

Masamitsu Konno et al.

NATURE COMMUNICATIONS (2019)

Article Cell & Tissue Engineering

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

Celeste M. Karch et al.

STEM CELL REPORTS (2019)

Article Biochemistry & Molecular Biology

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation

Qiu Li et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Non-canonical targets destabilize microRNAs in human Argonautes

June Hyun Park et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Biochemistry & Molecular Biology

A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease

P. Hemchandra Reddy et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

miR-106b inhibits tau phosphorylation at Tyr18 by targeting Fyn in a model of Alzheimer's disease

Wei Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Stem cell function and stress response are controlled by protein synthesis

Sandra Blanco et al.

NATURE (2016)

Article Multidisciplinary Sciences

New tools for studying microglia in the mouse and human CNS

Mariko L. Bennett et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Multidisciplinary Sciences

Messenger RNA modifications: Form, distribution, and function

Wendy V. Gilbert et al.

SCIENCE (2016)

Review Biochemistry & Molecular Biology

Small RNA Modifications: Integral to Function and Disease

Xudong Zhang et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Review Genetics & Heredity

Who Watches the Watchmen: Roles of RNA Modifications in the RNA Interference Pathway

Samantha B. Shelton et al.

PLOS GENETICS (2016)

Article Biochemistry & Molecular Biology

Proteinase-activated Receptor 2 Promotes Cancer Cell Migration through RNA Methylation-mediated Repression of miR-125b

Lan Yang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Medicine, Research & Experimental

Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau

Ismael Santa-Maria et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Multidisciplinary Sciences

N6-methyladenosine marks primary microRNAs for processing

Claudio R. Alarcon et al.

NATURE (2015)

Article Clinical Neurology

Primary age-related tauopathy (PART): a common pathology associated with human aging

John F. Crary et al.

ACTA NEUROPATHOLOGICA (2014)

Article Biochemistry & Molecular Biology

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

Julia Banzhaf-Strathmann et al.

EMBO JOURNAL (2014)

Article Biochemistry & Molecular Biology

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

Sandra Blanco et al.

EMBO JOURNAL (2014)

Article Neurosciences

Novel RNA Modifications in the Nervous System: Form and Function

John S. Satterlee et al.

JOURNAL OF NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b

Shuai Yuan et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Review Cell Biology

Regulation of microRNA biogenesis

Minju Ha et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Clinical Neurology

Progressive Supranuclear Palsy

Lawrence I. Golbe

SEMINARS IN NEUROLOGY (2014)

Review Biochemistry & Molecular Biology

Regulation of microRNA biogenesis and turnover by animals and their viruses

Valentina Libri et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Biochemistry & Molecular Biology

The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation

Shobbir Hussain et al.

MOLECULAR AND CELLULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

CLP1 links tRNA metabolism to progressive motor-neuron loss

Toshikatsu Hanada et al.

NATURE (2013)

Article Genetics & Heredity

Studying micro RNA Function and Dysfunction in Alzheimer’s Disease

Walter J. Lukiw et al.

Frontiers in Genetics (2013)

Article Genetics & Heredity

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

Muzammil Ahmad Khan et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2012)

Article Genetics & Heredity

Mutations in NSUN2 Cause Autosomal-Recessive Intellectual Disability

Lia Abbasi-Moheb et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2012)

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

Francesca Tuorto et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Article Geriatrics & Gerontology

GSPE interferes with tau aggregation in vivo: implication for treating tauopathy

Ismael Santa-Maria et al.

NEUROBIOLOGY OF AGING (2012)

Article Immunology

Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila

David W. Reid et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2012)

Review Developmental Biology

EXPLOITING DROSOPHILA GENETICS TO UNDERSTAND MICRORNA FUNCTION AND REGULATION

Qi Dai et al.

MICRORNAS IN DEVELOPMENT (2012)

Article Biochemistry & Molecular Biology

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

Sergio Casas-Tinto et al.

HUMAN MOLECULAR GENETICS (2011)

Article Neurosciences

The Power and Richness of Modelling Tauopathies in Drosophila

Katerina Papanikolopoulou et al.

MOLECULAR NEUROBIOLOGY (2011)

Article Biochemical Research Methods

Chemically defined conditions for human iPSC derivation and culture

Guokai Chen et al.

NATURE METHODS (2011)

Article Biochemistry & Molecular Biology

The RNA modification database, RNAMDB: 2011 update

William A. Cantara et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Genetics & Heredity

The RNA-Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

Sandra Blanco et al.

PLOS GENETICS (2011)

Article Cell Biology

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

Shobbir Hussain et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

Induced pluripotent stem cell lines derived from human somatic cells

Junying Yu et al.

SCIENCE (2007)

Article Cell Biology

Aurora-B regulates RNA methyltransferase NSUN2

Shiho Sakita-Suto et al.

MOLECULAR BIOLOGY OF THE CELL (2007)

Review Cell Biology

Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide

Christian Haass et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Review Neurosciences

The neuronal microRNA system

Kenneth S. Kosik

NATURE REVIEWS NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors

Michaela Frye et al.

CURRENT BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro

H Ksiezak-Reding et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2003)

Article Biochemistry & Molecular Biology

In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis

WB Stine et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Neurosciences

Proteinase-activated receptors in the nervous system

F Noorbakhsh et al.

NATURE REVIEWS NEUROSCIENCE (2003)