1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic Acid Acetoxymethyl Ester Loaded Reactive Oxygen Species Responsive Hyaluronic Acid-Bilirubin Nanoparticles for Acute Kidney Injury Therapy via Alleviating Calcium Overload Mediated Endoplasmic Retic...

Article Chemistry, Multidisciplinary

A dual-responsive hyaluronic acid nanocomposite hydrogel drug delivery system for overcoming multiple drug resistance

Yi Liu et al.

Summary: A dual-responsive hyaluronic acid nanocomposite hydrogel that can rapidly release core-shell nanoparticles in the tumor microenvironment and enhance chemotherapy through multiple reactions is proposed in this study.

CHINESE CHEMICAL LETTERS (2023)

添加到收藏夹

Review Nanoscience & Nanotechnology

ROS-Scavenging Therapeutic Hydrogels for Modulation of the Inflammatory Response

Ye Eun Kim et al.

Summary: Regulating the amount of reactive oxygen species (ROS) and utilizing ROS-scavenging hydrogels can effectively treat various inflammatory diseases, showing effects such as promoting wound healing, accelerating regeneration, and demonstrating synergy with other therapeutic molecules.

ACS APPLIED MATERIALS & INTERFACES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Kinetic control of Phytic acid/Lixisenatide/Fe (III) ternary nanoparticles assembly process for sustained peptide release

Yanan Wang et al.

Summary: A nanoscale ternary Lixisenatide sustained delivery system based on strong multivalent interactions among small molecular phytic acid, Lix and Fe3+ was developed in this study. The optimized formulation showed prolonged hypoglycemic effects and significant suppression of pathological damage of major organs, indicating great translational potential in chronic disease treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

添加到收藏夹

Letter Critical Care Medicine

The Effect of Filter Lifespan during Continuous Renal Replacement Therapy in Critically Ill Patients with Acute Kidney Injury on the Rate of New-Onset Infection: Analysis from the RICH Randomized Controlled Trial

Joachim Gerss et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

添加到收藏夹

Article Engineering, Biomedical

Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury

Weimin Tang et al.

Summary: This study demonstrates the synthesis of a novel siRNA carrier, C-CS, which shows potential for targeted delivery to injured kidneys. The C-CS/siRNA nanoparticles effectively accumulate and deliver therapeutic siRNAs to injured kidneys through CXCR4 binding, providing a new approach for AKI therapy.

BIOMATERIALS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Targeted co-delivery of daunorubicin and cytarabine based on the hyaluronic acid prodrug modified liposomes

George Frimpong Boafo et al.

Summary: A targeted co-delivery system of daunorubicin and cytarabine was developed, showing good stability and endocytosis capability, which could be utilized for the treatment of breast cancer.

CHINESE CHEMICAL LETTERS (2022)

添加到收藏夹

Article Urology & Nephrology

Low-Flow Acute Kidney Injury The Pathophysiology of Prerenal Azotemia, Abdominal Compartment Syndrome, and Obstructive Uropathy

Bruce A. Molitoris

Summary: AKI is a syndrome caused by various etiologies, and its pathophysiology overlaps. Early recognition and reversal are critical for preventing the severity and mortality of the disease.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Renal Nano-drug delivery for acute kidney Injury: Current status and future perspectives

Hui Nee Geo et al.

Summary: This article reviews the current status and future trajectories of renal nanomedicine research for the management of acute kidney injury (AKI). The use of nanosized drug carriers (NDCs) for the delivery of reno-protective agents is evaluated, with a focus on improving renal tissue targeting selectivity and efficacy. The need to identify accumulation sites of NDCs in renal tissues during in vivo assessments is highlighted.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Cell Biology

Reducing ischemic kidney injury through application of a synchronization modulation electric field to maintain Na+ /K+-ATPase functions

Wei Chen et al.

Summary: This study demonstrates the potential therapeutic effect of using a synchronization modulation electric field to activate Na/K pumps and maintain cellular functions during renal ischemia-reperfusion injury.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Secretory pathway Ca2+-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry

Myungjun Ko et al.

Summary: This study investigates the mechanism of how secretory pathway Ca2+-ATPase SPCA2 promotes cell cycle progression and survival in mammary epithelial cells through store-independent Ca2+ entry via plasma membrane Orai1 channels. The research reveals that silencing SPCA2 expression or removing extracellular Ca2+ leads to mitochondrial ROS production, DNA damage, cell cycle arrest, and apoptosis. Additionally, SPCA2-mediated Ca2+ entry into mitochondria is essential for cellular respiration and mitochondrial membrane potential generation.

REDOX BIOLOGY (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Design of Diselenide-Bridged Hyaluronic Acid Nano-antioxidant for Efficient ROS Scavenging to Relieve Colitis

Jiaqi Xu et al.

Summary: Overproduction of reactive oxygen species (ROS) is a key characteristic of inflammatory bowel disease (IBD). This study developed a nanoformulation, called diselenide-bridged hyaluronic acid nanogel (SeNG), which specifically accumulated in colitis tissue and showed significant anti-inflammatory effects in a mouse model of colitis. Mechanistically, SeNG reduced ROS levels through direct elimination and up-regulation of the Nrf2/HO-1 signal pathway.

ACS NANO (2022)

添加到收藏夹

Article Multidisciplinary Sciences

The RalGAPα1-RalA signal module protects cardiac function through regulating calcium homeostasis

Sangsang Zhu et al.

Summary: RalGAP alpha 1-RalA signal nexus plays a key role in regulating calcium homeostasis in cardiomyocytes through the calcium pump SERCA2a, which helps maintain cardiac function under pressure overload conditions.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

Dong-Hyun Kim et al.

Summary: This study demonstrates that activated FXR regulates the transcription of ferroptosis-related genes and protects against cisplatin-induced AKI.

REDOX BIOLOGY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Inflammation in kidney repair: Mechanism and therapeutic potential

Ying Fu et al.

Summary: The kidney has the ability to repair itself after acute kidney injury, but severe or persistent damage can lead to chronic kidney disease. Maladaptive kidney repair involves inflammation as a key component, with interactions between kidney cells and the immune system playing a crucial role. Further research is needed to discover biomarkers and therapeutic targets for kidney repair. This review summarizes the latest progress in understanding the immune response and inflammation during maladaptive kidney repair, highlighting the interactions between immune cells and kidney cells and discussing the potential of targeting inflammation-related pathways.

PHARMACOLOGY & THERAPEUTICS (2022)

添加到收藏夹

Letter Medicine, General & Internal

Extracorporeal Kidney-Replacement Therapy for Acute Kidney Injury

Dominique Vodovar et al.

Summary: This article discusses the importance and effectiveness of using extracorporeal kidney-replacement therapy in poisonings, even in the absence of acute kidney injury, to rapidly remove toxicants and save lives.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

添加到收藏夹

Review Anesthesiology

Pharmacological interventions for the prevention of renal injury in surgical patients: a systematic literature review and meta-analysis

Suraj Pathak et al.

Summary: This systematic review summarized the results of recent RCTs evaluating pharmacological interventions for renoprotection in people undergoing surgery, showing that there are multiple effective pharmacological interventions for renal protection in surgical patients based on the analysis of 228 trials.

BRITISH JOURNAL OF ANAESTHESIA (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Hyaluronic acid and albumin based nanoparticles for drug delivery

Can Lei et al.

Summary: The combined utilization of albumin and HA as nanocarriers offers numerous advantages, including efficient targeting, reducible particle size, and pH and/or hyaluronidase sensitive drug release, contributing significantly to drug delivery systems.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Article Urology & Nephrology

Adverse Maternal and Fetal Outcomes in a Novel Experimental Model of Pregnancy after Recovery from Renal Ischemia-Reperfusion Injury

Ellen E. Gillis et al.

Summary: Recent clinical studies show that women with a history of acute kidney injury may experience poor maternal and fetal outcomes during pregnancy, despite fully recovering renal function prior to conception. The mechanisms behind these adverse outcomes in pregnancy following AKI remain unclear.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

添加到收藏夹

Article Cell Biology

Mapping and functional characterization of murine kidney injury molecule-1 proteolytic cleavage site

Saranga Sriranganathan et al.

Summary: The shedding of KIM-1 in mice is mediated by the enzyme ADAM10 at the isoleucine I202 cleavage site, which is essential for the phagocytic clearance of apoptotic cells. Mutating I202 to alanine or glutamine significantly reduces KIM-1 shedding and efferocytosis. Additionally, exogenously added shed KIM-1 can rescue impaired phagocytosis, indicating a potential functional role of soluble KIM-1 in modulating efferocytosis during AKI.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

添加到收藏夹

Review Pathology

Endoplasmic Reticulum Calcium Homeostasis in Kidney Disease Pathogenesis and Therapeutic Targets

Sun-Ji Park et al.

Summary: Maintaining Ca2+ homeostasis is crucial for cellular function and survival, with the endoplasmic reticulum acting as the major intracellular Ca2+ store. Dysregulation of ER Ca2+ homeostasis is associated with various diseases, particularly in kidney diseases, highlighting the importance of ER Ca2+ channels, pumps, and binding proteins. Despite advancements in understanding, treatment for ER Ca2+ imbalance in kidney diseases remains elusive.

AMERICAN JOURNAL OF PATHOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate

Natalia Siwecka et al.

Summary: IRE1 is a key protein in the UPR signaling pathway, with implications for cell survival and apoptosis in various human pathologies. Its increased activity in conditions such as cancer, neurodegeneration, inflammation, and metabolic disorders suggests that modulation of IRE1 could provide promising therapeutic strategies. Understanding the molecular characteristics and activation of IRE1 may lead to the design of specific modulators for drug development.

BIOMEDICINES (2021)

添加到收藏夹

Review Critical Care Medicine

Acute kidney injury in the critically ill: an updated review on pathophysiology and management

Peter Pickkers et al.

Summary: AKI is now recognized as a complex and heterogeneous syndrome that not only impacts acute morbidity and mortality, but also long-term prognosis of patients. This review provides updates on various aspects of AKI in critically ill patients, focusing on prediction and early detection, pathophysiology, different phenotypes of AKI, nephrotoxicity and organ cross-talk, prevention, supportive treatment, and long-term risks post-AKI.

INTENSIVE CARE MEDICINE (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications

Yi Zhao et al.

Summary: Nanotechnology holds profound potential in the management of acute kidney injury, providing innovative strategies to improve treatment efficacy. Various nanotechnology-based drug delivery systems show unique advantages in treating AKI by enhancing both efficacy and safety concurrently.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hyaluronic acid coated bilirubin nanoparticles attenuate ischemia reperfusion-induced acute kidney injury

Zhi-Wei Huang et al.

Summary: Acute kidney injury (AKI) is a common pathological process associated with high morbidity and mortality worldwide. Bilirubin, with its antioxidant, anti-inflammatory, and anti-apoptotic properties, shows promise as a therapeutic candidate for AKI. Nanotechnology-mediated therapy, particularly using hyaluronic acid-coated epsilon-polylysine-bilirubin conjugate nanoparticles (nHA/PLBR), has shown potential for targeted delivery and enhanced efficacy in protecting against renal injury induced by oxidative stress and inflammation in AKI.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions

Yi Huang et al.

Summary: Kidney-targeted nanoparticles offer a promising approach for drug delivery to diseased tissues with reduced side effects, and understanding the impact of nanoparticle properties such as size, charge, shape, and material density on kidney interaction is crucial for designing effective drug delivery systems for chronic kidney disease. Active targeting strategies can enhance nanoparticle retention in the kidney, showing potential for improving treatment outcomes in kidney diseases.

JOURNAL OF CONTROLLED RELEASE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER

David M. Booth et al.

Summary: The study shows that individual mitochondria generate oxidative bursts at interorganellar contact sites, with Ca2+ channels directly sensing these bursts and responding with transient Ca2+ transients. Under mitochondrial stress or apoptotic stimuli, the frequency and amplitude of the oxidative bursts can be increased.

MOLECULAR CELL (2021)

添加到收藏夹

Article Chemistry, Physical

Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

Yonghyun Lee et al.

NATURE MATERIALS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes

Zhiyu He et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Review Urology & Nephrology

Long-term outcomes of acute kidney injury and strategies for improved care

Matthew T. James et al.

NATURE REVIEWS NEPHROLOGY (2020)

添加到收藏夹

Article Cell Biology

Improvement of Flavonoids in Lemon Seeds on Oxidative Damage of Human Embryonic Kidney 293T Cells Induced by H2O2

Dingyi Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

添加到收藏夹

Article Nanoscience & Nanotechnology

Self-Assembled Lecithin/Chitosan Nanoparticles Based on Phospholipid Complex: A Feasible Strategy to Improve Entrapment Efficiency and Transdermal Delivery of Poorly Lipophilic Drug

Wujun Dong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

添加到收藏夹

Article Urology & Nephrology

Spatiotemporal ATP Dynamics during AKI Predict Renal Prognosis

Shinya Yamamoto et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Renal ischemia/reperfusion injury: An insight on in vitro and in vivo models

Niharika Shiva et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule

Di Liu et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Therapeutic application and construction of bilirubin incorporated nanoparticles

Qing Yao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Review Critical Care Medicine

Fluid Management in Acute Kidney Injury

Marlies Ostermann et al.

CHEST (2019)

添加到收藏夹

Review Urology & Nephrology

Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

Sadudee Peerapornratana et al.

KIDNEY INTERNATIONAL (2019)

添加到收藏夹

Article Engineering, Biomedical

Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes

Di Liu et al.

BIOMATERIALS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney

Victor Naumenko et al.

JOURNAL OF CONTROLLED RELEASE (2019)

添加到收藏夹

Article Urology & Nephrology

Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect against AKI

Takuto Chiba et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Elimination of Intracellular Calcium Overload by BAPTA-AM-Loaded Liposomes: A Promising Therapeutic Agent for Acute Liver Failure

Zailin Fu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

添加到收藏夹

Article Engineering, Biomedical

Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis

Hang Yu et al.

BIOMATERIALS (2019)

添加到收藏夹

Review Medicine, General & Internal

Acute kidney injury

Claudio Ronco et al.

LANCET (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

BAPTA-AM Nanoparticle for the Curing of Acute Kidney Injury Induced by Ischemia/Reperfusion

Zhiyu He et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2018)

添加到收藏夹

Article Physiology

Comparison of ischaemia-reperfusion-induced acute kidney injury by clamping renal arteries, veins or pedicles in anaesthetized rats

Seyed Mohammad Owji et al.

EXPERIMENTAL PHYSIOLOGY (2018)

添加到收藏夹

Article Engineering, Biomedical

Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin

Zhiyu He et al.

BIOMATERIALS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy

Yonghyun Lee et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

Satoko Arai et al.

NATURE MEDICINE (2016)

添加到收藏夹

Article Urology & Nephrology

Blood Kidney Injury Molecule-1 Is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD in Type I Diabetes

Venkata. S. Sabbisetti et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

添加到收藏夹

Review Physiology

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AND ROS-INDUCED ROS RELEASE

Dmitry B. Zorov et al.

PHYSIOLOGICAL REVIEWS (2014)

添加到收藏夹

Article Multidisciplinary Sciences

CD44-Deficiency Attenuates the Immunologic Responses to LPS and Delays the Onset of Endotoxic Shock-Induced Renal Inflammation and Dysfunction

Elena Rampanelli et al.

PLOS ONE (2013)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Role of Intracellular Ca2+ and Na+/Ca2+ Exchanger in the Pathogenesis of Contrast-Induced Acute Kidney Injury

Dingping Yang et al.

BIOMED RESEARCH INTERNATIONAL (2013)

添加到收藏夹

Review Cell Biology

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Claudio Hetz

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

添加到收藏夹

Article Urology & Nephrology

CD44 expression in renal ischemia-reperfusion injury in rats

Burak Kocak et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2009)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Ca2+ channel subtypes and pharmacology in the kidney

Koichi Hayashi et al.

CIRCULATION RESEARCH (2007)

添加到收藏夹

Article Urology & Nephrology

Protection against renal ischemia reperfusion injury by CD44 disruption

KMA Rouschop et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2005)

添加到收藏夹

Review Cell Biology

Regulation of cell death: The calcium-apoptosis link

S Orrenius et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

添加到收藏夹

Article Urology & Nephrology

Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury

WK Han et al.

KIDNEY INTERNATIONAL (2002)

添加到收藏夹

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic Acid Acetoxymethyl Ester Loaded Reactive Oxygen Species Responsive Hyaluronic Acid-Bilirubin Nanoparticles for Acute Kidney Injury Therapy via Alleviating Calcium Overload Mediated Endoplasmic Reticulum Stress

相关参考文献

导出引文

分享论文