☆ 4.8 Article

Homotypic Targeted Photosensitive Nanointerferer for Tumor Cell Cycle Arrest to Boost Tumor Photoimmunotherapy

ACS NANO (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Multidisciplinary

Tumor-Microenvironment-Activatable Polymer Nano-Immunomodulator for Precision Cancer Photoimmunotherapy

Jing Liu et al.

Summary: This study reports a smart semiconducting polymer nano-immunomodulator that can achieve precise regulation of photodynamic immunotherapy for cancer in the acidic tumor microenvironment. The release of immunogenic factors and TLR7 agonist at the tumor site activates dendritic cells, leading to strong antitumor activities. Additionally, the nano-immunomodulator can directly eradicate tumors and induce immunogenic cancer cell death. This approach enhances systemic antitumor immune responses, resulting in inhibition of tumor growth and metastasis.

ADVANCED MATERIALS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Semiconducting Polymer Nano-regulators with Cascading Activation for Photodynamic Cancer Immunotherapy

Shasha He et al.

Summary: This study introduces a novel semiconducting polymer nano-regulator (SPNT) that can produce singlet oxygen under near-infrared photoirradiation, inducing immunogenic apoptosis. By regulating immune-related factors, SPNT-mediated combination photodynamic immunotherapy successfully suppressed tumor growth and lung metastasis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics

Yue Sun et al.

Summary: This study reports the development of conjugated peptides that can form coacervate microdroplets through liquid-liquid phase separation. These microdroplets have the ability to easily cross the cell membrane and can recruit and release macromolecular therapeutic agents, making them promising for treating various diseases.

NATURE CHEMISTRY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells

Jingyao Tu et al.

Summary: This study investigated the therapeutic potential of nintedanib and alpha PD-L1 combination therapy in tumor treatment. The results showed significant improvements in the antitumor effects and positive impact on lung complications with this combination therapy.

THERANOSTICS (2022)

添加到收藏夹

Article Cell Biology

NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

Hongwei Lv et al.

Summary: The study reveals that NAMPT enzyme drives PD-L1 expression in various tumors and governs tumor immune evasion through CD8(+) T cell regulation. NAD(+) metabolism maintains the activity and expression of Tet1, which plays a critical role in PD-L1 expression on tumors.

CELL METABOLISM (2021)

添加到收藏夹

Article Polymer Science

A Single-wavelength NIR-triggered Polymer for in Situ Generation of Peroxynitrite (ONOO-) to Enhance Phototherapeutic Efficacy

Xiang Zhang et al.

Summary: Phototherapies such as PDT and PTT are promising non-invasive cancer treatments, but often limited by technical defects. A novel nanoplatform has been developed to enhance therapy by in situ generating peroxynitrite (ONOO-), showing potential as a new approach in cancer treatment.

CHINESE JOURNAL OF POLYMER SCIENCE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA

Chunhui Li et al.

Summary: The study synthesized a series of quaternary ammonium-based amphiphilic triblock polymers with a pH-sensitive hydrophobic core that can rapidly release internalized siRNA in endosomal pH environment, leading to enhanced gene silencing activity and significant therapeutic effects in tumor models.

NANO LETTERS (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection

Jing Zhang et al.

Summary: The study introduces an injectable hydrogel system that stimulates tumoricidal immunity after GBM surgical resection, effectively reducing its recurrence. This system induces immunogenic cell death and sustained T-cell infiltration to attack residual tumor cells, significantly suppressing postoperative GBM recurrence.

NATURE NANOTECHNOLOGY (2021)

添加到收藏夹

Review Oncology

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

Deborah Blythe Doroshow et al.

Summary: PD-L1 expression is currently the best predictor of responsiveness to immune-checkpoint inhibitors, despite challenges in clinical use such as variability in different assays and cut-off points, as well as the lack of prospective comparisons with clinical outcomes. Nevertheless, several immunohistochemical assays have been approved for clinical use, with implications for pathology services and potential impacts on clinical outcomes. Comparison of FDA-approved PD-L1 assays, understanding of the varying implications of PD-L1 expression across different tumour types, and exploration of novel approaches to optimize its clinical utility are important topics for further research and practice.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Lizhi Liu et al.

Summary: Cell membrane coated nanoparticles have unique properties that make them attractive for nanomedical applications, but it has been found that most nanoparticles are only partially coated. This partial coating can impact the biological fate of the nanoparticles.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Singlet Oxygen Reservoir Based on Poly-Pyridone and Porphyrin Nanoscale Metal-Organic Framework for Cancer Therapy

Bo-Ru Xie et al.

Summary: The study demonstrated successful loading of a methacrylate-modified pyridone derivative into a porphyrin nanoscale metal-organic framework, forming poly-pyridone for storing and releasing singlet oxygen, leading to cancer cell death in solid tumors and lung metastasis with no intracellular oxygen consumption.

CCS CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy

Jingyi Zhu et al.

ACS NANO (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Keisuke Yamamoto et al.

NATURE (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell

Dario Manzanares et al.

PHARMACEUTICS (2020)

添加到收藏夹

Article Chemistry, Physical

Collaborative assembly-mediated siRNA delivery for relieving inflammation-induced insulin resistance

Shiyang Shen et al.

NANO RESEARCH (2020)

添加到收藏夹

Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death

Hongzhang Deng et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

NIR-Triggered Phototherapy and Immunotherapy via an Antigen-Capturing Nanoplatform for Metastatic Cancer Treatment

Meng Wang et al.

ADVANCED SCIENCE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hyaluronidase with pH-responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic-Immunotherapy of Cancer

Hairong Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

添加到收藏夹

Review Nanoscience & Nanotechnology

Cancer nanomedicine for combination cancer immunotherapy

Jutaek Nam et al.

NATURE REVIEWS MATERIALS (2019)

添加到收藏夹

Article Immunology

Engineering nanoparticles to locally activate T cells in the tumor microenvironment

Dangge Wang et al.

SCIENCE IMMUNOLOGY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multiantigenic Nanoformulations Activate Anticancer Immunity Depending on Size

Shengxian Li et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

添加到收藏夹

Article Oncology

Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial

J. M. Weiss et al.

ANNALS OF ONCOLOGY (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Multiple effects of CDK4/6 inhibition in cancer: From cell cycle arrest to immunomodulation

Mara Bonelli et al.

BIOCHEMICAL PHARMACOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance

Jinfang Zhang et al.

NATURE (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Nanoscale Metal-Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

Guangxu Lan et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Review Medicine, General & Internal

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

Michael A. Postow et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Recent Progresses in Phototherapy-Synergized Cancer Immunotherapy

Chee Wee Ng et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment

Bing Feng et al.

ADVANCED MATERIALS (2018)

添加到收藏夹

Article Oncology

Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer

Yihao Mao et al.

CANCER MANAGEMENT AND RESEARCH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

CDK4/6 inhibition triggers anti-tumour immunity

Shom Goel et al.

NATURE (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Overcoming cellular barriers for RNA therapeutics

Steven F. Dowdy

NATURE BIOTECHNOLOGY (2017)

添加到收藏夹

Review Oncology

Cancer nanomedicine: progress, challenges and opportunities

Jinjun Shi et al.

NATURE REVIEWS CANCER (2017)

添加到收藏夹

Article Oncology

Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

Zhi Ling Teo et al.

CANCER RESEARCH (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cancer Cell Membrane Camouflaged Cascade Bioreactor for Cancer Targeted Starvation and Photodynamic Therapy

Shi-Ying Li et al.

ACS NANO (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Padmanee Sharma et al.

CELL (2017)

添加到收藏夹

Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Size-Controlled Synthesis of Porphyrinic Metal-Organic Framework and Functionalization for Targeted Photodynamic Therapy

Jihye Park et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Nanoscience & Nanotechnology

Intracellular trafficking and exocytosis of a multi-component siRNA nanocomplex

Ravi S. Shukla et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

添加到收藏夹

Article Nanoscience & Nanotechnology

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

Saeid Zanganeh et al.

NATURE NANOTECHNOLOGY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi-Peptide Nanoparticles to Tumor-Associated Macrophages and Cancer Cells

Joao Conde et al.

ADVANCED FUNCTIONAL MATERIALS (2015)

添加到收藏夹

Review Genetics & Heredity

Knocking down disease: a progress report on siRNA therapeutics

Anders Wittrup et al.

NATURE REVIEWS GENETICS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Systematic pan-cancer analysis of tumour purity

Dvir Aran et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

Ronnie H. Fang et al.

NANO LETTERS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Construction of Ultrastable Porphyrin Zr Metal-Organic Frameworks through Linker Elimination

Dawei Feng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape

Jerome Gilleron et al.

NATURE BIOTECHNOLOGY (2013)

添加到收藏夹

Article Oncology

Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin

Abhishek D. Garg et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

添加到收藏夹

Review Chemistry, Multidisciplinary

Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance

Mar Creixell et al.

NANO TODAY (2012)

添加到收藏夹

Article Medicine, General & Internal

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Suzanne L. Topalian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

添加到收藏夹

Review Oncology

Treating metastatic cancer with nanotechnology

Avi Schroeder et al.

NATURE REVIEWS CANCER (2012)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Rapid translocation of nanoparticles from the lung airspaces to the body

Hak Soo Choi et al.

NATURE BIOTECHNOLOGY (2010)

添加到收藏夹

Review Oncology

Cell cycle, CDKs and cancer: a changing paradigm

Marcos Malumbres et al.

NATURE REVIEWS CANCER (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.