Cold Nanozyme for Precise Enzymatic Antitumor Immunity

Article Chemistry, Multidisciplinary

Self-Adaptive Single-Atom Catalyst Boosting Selective Ferroptosis in Tumor Cells

Fangfang Cao et al.

Summary: A self-adaptive ferroptosis platform has been developed by engineering a DNA modulator onto the surface of single-atom nanozymes, enabling selective and safe antitumor response and promoting the development of selective cancer therapy.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

A Closed-Loop Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy

Yaqian Du et al.

Summary: This study reports a closed-loop therapy system based on photothermal enhancement of ferroptosis and immunotherapy. By combining mesoporous nanospheres with gold nanoparticles, researchers successfully enhanced tumor cell ferroptosis and triggered an immune response. The system is effective in both killing the primary tumor and inhibiting tumor metastasis.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A Bioinspired Five-Coordinated Single-Atom Iron Nanozyme for Tumor Catalytic Therapy

Bolong Xu et al.

Summary: Single-atom nanozymes are a new research frontier in the biomedical fields. A melamine-mediated pyrolysis activation strategy has been used to controllably fabricate iron-based SAzymes with a five-coordinated structure (FeN5). The FeN5 SAzyme shows excellent peroxidase-like activity and significantly enhanced antitumor effect in vitro and in vivo.

ADVANCED MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Biocomputation with MnTiO3 Piezoelectric Enzymes for Programed Catalysis of Tumor Death

Qianqian Xu et al.

Summary: This study presents a concept of using piezoelectric enzymes in combination with biocomputation ability to achieve precise control over enzymatic catalysis in tumors. A biocomputing platform based on a Boolean logic-based algorithm is constructed, which outputs cytotoxicity for programed tumor killing. The combination of piezoelectric enzymes and biocomputation strategy provides an intelligent and effective approach for catalytic tumor eradication.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

Feng Wu et al.

Summary: The nanomedicine developed in this study integrates nanocarriers and clinical drugs, exhibiting peroxidase mimicking activities and depleting glutathione in the tumor microenvironment, promoting reactive oxygen species-mediated tumor catalytic therapy, and restoring the chemical sensitivity of oxaliplatin, playing an important role in apoptosis and ferroptosis of tumor cells.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Glutathione Depletion-Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of Cold Tumor

Zhanwei Zhou et al.

Summary: This study developed dimersomes, lipid-like materials capable of depleting glutathione (GSH) in tumors and delivering therapeutic drugs, which enhanced ferroptosis therapy and immunotherapy for breast cancer.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Multidisciplinary Sciences

A scalable hyperthermic intravesical chemotherapy (HIVEC) setup for rat models of bladder cancer

J. W. Van Hattum et al.

Summary: The study presents a HIVEC setup compatible with orthotopic rat models, which provides precise temperature control of the bladder and can be used for large-scale experiments.

SCIENTIFIC REPORTS (2022)

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Article Chemistry, Multidisciplinary

Cycloacceleration of Reactive Oxygen Species Generation Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for Tumor Ferroptosis Therapy

Huimin Zhou et al.

Summary: This study proposes a new concept of cycloacceleration of reactive oxygen species (ROS) generation in tumor cells to achieve high-performance ferroptosis therapy (FT) for tumors. By preparing a magnetic resonance imaging (MRI) contrast agent and loading a drug, the hybrid nanoparticles can work with the tumor microenvironment and generate cyclic reactions in tumor cells, resulting in specific cycloacceleration of ROS generation for high-performance FT. Additionally, these nanoparticles can be used for MRI-guided tumor therapy.

SMALL (2022)

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Article Chemistry, Multidisciplinary

Conscription of Immune Cells by Light-Activatable Silencing NK-Derived Exosome (LASNEO) for Synergetic Tumor Eradication

Mengjie Zhang et al.

Summary: This study proposes a new type of light-activatable exosomes derived from NK cells, which can achieve tumor treatment by generating reactive oxygen species and gene silencing. These exosomes not only exhibit strong cytotoxicity, but also recruit various types of immune cells to restore immunological surveillance in the tumor microenvironment. The manufacturing process is simple and controllable, showing great potential.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Cold-catalytic antitumor immunity with pyroelectric black phosphorus nanosheets

Xianbo Wu et al.

Summary: Catalytic nanomedicine with the characteristics of catalysts brings unique properties to biomedicine. Cold-catalysts have been explored for antitumor therapy, showing potential for preventing tumor metastasis and recurrence through immunomodulation. This opens up exciting opportunities for the development of cold-catalytic nanomedicine.

CHEMICAL SCIENCE (2022)

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Article Chemistry, Multidisciplinary

An Ultrasmall SnFe2O4 Nanozyme with Endogenous Oxygen Generation and Glutathione Depletion for Synergistic Cancer Therapy

Lili Feng et al.

Summary: The newly introduced TME-modulated nanozyme combines photothermal therapy, photodynamic therapy, and chemodynamic therapy for efficient tumor treatment in the tumor microenvironment. This all-in-one nanozyme demonstrates promising therapeutic effects and offers a new perspective for the design of other TME-based anticancer strategies.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

2D Piezoelectric Bi2MoO6 Nanoribbons for GSH-Enhanced Sonodynamic Therapy

Yushan Dong et al.

Summary: In this study, ultrathin 2D Bi2MoO6-poly(ethylene glycol) nanoribbons were designed as piezoelectric sonosensitizers for sonodynamic therapy (SDT), aiming to reduce the scavenging capacity of reactive oxygen species (ROS) and elevate ROS production by consuming endogenous GSH and promoting electron-hole pair separation. The synthesized nanoribbons showed excellent computed tomography imaging of tumors and significant tumor suppression in vitro and in vivo, demonstrating a potential two-step enhancement SDT process activated by endogenous GSH and amplified by exogenous ultrasound.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Injectable Adhesive Hydrogel as Photothermal-Derived Antigen Reservoir for Enhanced Anti-Tumor Immune

Man Fan et al.

Summary: The study presents a novel injectable adhesive hydrogel loaded with MnO2 nanoparticles that induce immunogenic cell death and release tumor protein antigens to stimulate the immune response, effectively inhibiting tumor growth.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies

Evangelia Bolli et al.

Summary: The site-specific and quantitative coupling of Toll-like receptor agonist with single chain antibody fragments can repolarize macrophages, leading to a decline in tumor growth and enhancement of anti-tumor immune responses.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Realizing Fast Charge Diffusion in Oriented Iron Carbodiimide Structure for High-Rate Sodium-Ion Storage Performance

Jiayin Li et al.

Summary: Iron carbodiimide demonstrates improved charge-transfer kinetics and high rate performance in sodium-ion battery due to its covalent bonding structure. The oriented FeNCN crystallites exhibit rapid charge-transfer kinetics and high Na-ion storage capacity, providing ideas for rational structural design of metal carbodiimides for future high electrochemical performance.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Single-Atom Pd Nanozyme for Ferroptosis-Boosted Mild-Temperature Photothermal Therapy

Mengyu Chang et al.

Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Physical

Matching the kinetics of natural enzymes with a single-atom iron nanozyme

Shufang Ji et al.

Summary: By precisely controlling the electronic structure of the single-atom iron active center, FeN3P-SAzyme exhibits catalytic activity and kinetics comparable to natural enzymes, showing promising potential as an effective therapeutic strategy for inhibiting tumor cell growth.

NATURE CATALYSIS (2021)

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Article Chemistry, Multidisciplinary

Nanomessenger-Mediated Signaling Cascade for Antitumor Immunotherapy

Henan Zhao et al.

Summary: A nanomessenger was prepared with signaling transduction cascades to amplify the regulatory activity of chemical messengers for antitumor immunotherapy. By releasing Ca2+ and H2S, the nanomessenger synergistically elevated intracellular Ca2+ stress and mediated cell death, while zinc protoporphyrin suppressed the antideath effect of tumor cells, leading to tumor eradication and immunological memory formation to prevent metastasis and recurrence.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Pyroelectric Catalysis-Based Nano-Lymphatic Reduces Tumor Interstitial Pressure for Enhanced Penetration and Hydrodynamic Therapy

Yuchu He et al.

Summary: The deficiency of lymphatic reflux in tumors leads to increased tumor interstitial pressure, affecting the penetration of nanomedicine. By designing a Nanolymphatic system to decrease TIP, photothermal therapy and decomposition of tumor interstitial fluid can be achieved, effectively inhibiting tumor proliferation and recurrence.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

A Robust Narrow Bandgap Vanadium Tetrasulfide Sonosensitizer Optimized by Charge Separation Engineering for Enhanced Sonodynamic Cancer Therapy

Shuang Liang et al.

Summary: By engineering platinum and glutathione-modified vanadium tetrasulfide nanodendrites as a new sonosensitizer, the charge lifetime is extended and ROS production activity is significantly increased, leading to efficient tumor suppression.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Engineering Single-Atomic Iron-Catalyst-Integrated 3D-Printed Bioscaffolds for Osteosarcoma Destruction with Antibacterial and Bone Defect Regeneration Bioactivity

Liying Wang et al.

Summary: The study introduces a scaffold engineering strategy that integrates highly active single-atomic iron catalysts into bioactive glass scaffold for effective osteosarcoma treatment and bacterial sterilization. The localized hyperthermia-reinforced nanocatalytic therapeutics offer efficient osteosarcoma ablation while preventing chronic osteomyelitis. This approach provides a clinically feasible strategy for overall osteosarcoma therapeutics, bacterial inhibition, and tissue regeneration.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Plasmon-pyroelectric nanostructures used to produce a temperature-mediated reactive oxygen species for hypoxic tumor therapy

Yun Chang et al.

Summary: The newly designed Au@BTO CSNSs nanostructures generate a temperature-mediated oxygen-independent PDT, which can play a significant role in hypoxic tumor microenvironment and show great potential for hypoxic tumor therapy.

NANO TODAY (2021)

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Article Chemistry, Multidisciplinary