4.8 Article

Rescuing Cardiac Cells and Improving Cardiac Function by Targeted Delivery of Oxygen- Releasing Nanoparticles after or Even before Acute Myocardial Infarction

期刊

ACS NANO
卷 16, 期 11, 页码 19551-19566

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c10043

关键词

acute myocardial infarction; controlled release of oxygen; nanoparticles; targeted delivery; myocardial repair

资金

  1. US National Institutes of Health
  2. [R 0 1 HL 1 3 8 1 7 5]
  3. [R01HL138353]
  4. [R01EB022018]
  5. [R01AG056919]
  6. [R01HL153262]
  7. [R01HL164062]
  8. [R01DK133949]

向作者/读者索取更多资源

This study presents infarcted heart-targeting, oxygen-releasing nanoparticles that can be delivered by intravenous injection at the acute myocardial infarction (MI) stage and specifically accumulate in the infarcted heart. These nanoparticles enhance cardiac cell survival, stimulate angiogenesis, and suppress fibrosis without inducing substantial inflammation and reactive oxygen species overproduction.
Myocardial infarction (MI) causes massive cell death due to restricted blood flow and oxygen deficiency. Rapid and sustained oxygen delivery following MI rescues cardiac cells and restores cardiac function. However, current oxygen-generating materials cannot be administered during acute MI stage without direct injection or suturing methods, both of which risk rupturing weakened heart tissue. Here, we present infarcted heart-targeting, oxygen-releasing nanoparticles capable of being delivered by intravenous injection at acute MI stage, and specifically accumulating in the infarcted heart. The nanoparticles can also be delivered before MI, then gather at the injured area after MI. We demonstrate that the nanoparticles, delivered either pre-MI or post-MI, enhance cardiac cell survival, stimulate angiogenesis, and suppress fibrosis without inducing substantial inflammation and reactive oxygen species overproduction. Our findings demonstrate that oxygen delivering nanoparticles can provide a nonpharmacological solution to rescue the infarcted heart during acute MI and preserve heart function.

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