期刊
ACS NANO
卷 16, 期 12, 页码 20567-20576出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c07306
关键词
Noble Metal Catalyst; Nanozyme; Nanoceria; Oxygen Vacancy; Reactive Oxygen Species; Anti-inflammatory Therapy
类别
资金
- National Key R&D Program of China
- National Natural Science Foundation of China
- PAPD Program
- Fundamental Research Funds for the Central Universities
- Jiangsu Provincial Key RD Program
- [2021YFF1200700]
- [2019YFA0709200]
- [21874067]
- [21722503]
- [11874199]
- [021314380195]
- [BE2022836]
Designing metal-metal oxide heteronanostructures is important for technological applications. This study developed a facile deposition strategy to produce metal nanocrystals on the surface of cerium oxide nanospheres, which exhibited multienzyme-like activities for anti-inflammatory therapies.
Designing metal-metal oxide heteronanostructures with synergistic and superior activities (unattainable in the case of a single entity) is of great interest for a wide range of technological applications. Traditional synthetic strategies typically require reducing agents, stabilizing ligands, or high temperature reductive treatment to produce oxide-supported metals. Herein, a facile noble metal deposition strategy is developed to produce silver, gold, and platinum nanocrystals on the surface of hollow mesoporous cerium oxide nanospheres without any pretreatment. Unlike the galvanic replacement reaction, the developed protocol employs the innate reductive potential of CeO2 to produce a high density of ultrafine noble metal nanocrystals homogeneously immobilized onto the surface of CeO2 nanospheres. The multienzyme-like activities (i.e., superoxide dismutase-like and catalase-like) of CeO2@ metal nanostructures, originating from CeO2 and metal nanoparticles, were effectively utilized for anti-inflammatory therapies in two in vivo models. This oxygen vacancy-mediated reduction strategy can be generalized to produce diverse metal-metal oxide nanostructures for a wide range of applications.
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