期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 50, 页码 55354-55364出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c15864
关键词
anion exchange; cationic metal-organic frameworks; human serum albumin; sorption mechanism; uremic toxin
资金
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province
- [21876124]
- [LR21B060001]
- [LQ21B070004]
In the field of replacement of conventional dialysis treatment, the search for superior materials to remove protein-bound uremic toxins is a challenge. This study demonstrates the potential of cationic metal-organic frameworks as sorbents for decontaminating uremic toxins, showing high sorption capacity and fast sorption kinetics.
In the field of replacement of conventional dialysis treatment, searching superior materials for removal of protein-bound uremic toxins is a challenge on account of strong interactions between proteins and uremic toxins. Herein, we first adopted cationic metal-organic frameworks (MOFs), ZJU-X6 and ZJU-X7, as sorbents to decontaminate uremic toxins (p-cresyl sulfate and indoxyl sulfate). ZJU-X6 and ZJU-X7 exhibited innate advantage for sequestration of uremic toxins by utilizing a positive charge framework with exchangeable anions. Especially, ZJU-X6 showed a higher sorption capacity and faster sorption kinetics than those of most reported materials. Moreover, the cationic MOF materials could selectively remove uremic toxins even if in the presence of competitive chloride ions and proteins. Meanwhile, pair distribution function (PDF) and density functional theory (DFT) were employed to elucidate the sorption mechanism between uremic toxins and sorbents. This work suggests an attractive avenue for constructing new types of sorbents to eliminate uremic toxins for uremia treatment.
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