期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 50, 页码 55423-55430出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c18201
关键词
aggregation-induced enhancement (AIE) color encoding; full-color-tunable nanohydrogels; thermometer; intracellular temperature sensing; ultrahigh stability
资金
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Postdoctoral Program for Innovative Talents
- [22005110]
- [22031010]
- [22275062]
- [2020M672339]
- [BX20200141]
This study reports a full-color-tunable nanohydrogel with ultrahigh stability for intracellular temperature sensing. By synthesizing temperature-sensitive polymers with red, green, and blue fluorescence and easy mixing, full-color-tunable fluorescent nanohydrogels were obtained. Further study indicated that the nanohydrogels exhibited excellent performance in intracellular temperature sensing due to their ultrahigh stability.
Full-color-tunable hydrogels with ultrahigh stability can be used in various fields, including intracellular temperature sensing. However, constructing full-color-tunable organic nanohydrogels with excellent biocompatibility and stability for intracellular temperature sensing remains a great challenge. Here, we report a full-color-tunable nanohydrogel with ultrahigh stability as an intracellular nanothermometer. Three types of temperature-sensitive polymers with red, green, and blue fluorescence were synthesized. Through easy mixing of these three polymers with regulation of the mass ratio, these polymers can be encoded to full-color-tunable fluorescent nanohydrogels, including nanohydrogels with white-light emission (NWLEs), with sizes of about 200 nm in aqueous media. Further study suggested that the as-obtained NWLEs exhibited good performance in intracellular temperature sensing because of their ultrahigh stability on their fluorescence properties and morphologies.
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