期刊
JOURNAL OF NEUROCHEMISTRY
卷 138, 期 5, 页码 653-693出版社
WILEY
DOI: 10.1111/jnc.13667
关键词
Alzheimer disease; blood-brain barrier; innate immunity; macrophage; non-steroidal anti-inflammatory drugs (NSAIDs); Venusberg Neuroinflammation Meeting Bonn 2015
资金
- NIH [R01 NS076794, R21 NS048522, R01 AG30149, R01AG023012, R01NS074804, R01AG043522, R01AG030209, R21AG033914, P50 AG047366, R01 NS093920, U01 AG050636, P30 AG028383, K99 AG044445]
- Alzheimer's Association Zenith Fellows Award [ZEN-10-174633]
- American Federation of Aging Research/Ellison Medical Foundation Julie Martin Mid-Career Award in Aging Research [M11472]
- Cure Alzheimer's Fund Award
- Zilkha Neurogenetic institute
- Killian J. and Caroline F. Schmitt Foundation Program on Integrative Brain Research
- Alzheimer's Association and BrightFocus Foundation
- Cure Alzheimer's Fund (CAF)
- NIH RFI [AG051485 01]
- Alzheimer's Association
- American Federation for Aging Research
- Bright Focus
- Wellcome Trust
- Alzheimer's Society UK
- Science Foundation Ireland [11/PI/2014]
- Higher Education Authority, Ireland
- Kentucky Spinal Cord AMP
- Head Injury Research Trust (KSCHIRT)
- Thome Memorial Foundation
- Swedish Medical Research Council [11548]
- AFA Research Foundation
- ALF Goteborg [11392]
- Sten A. Olsson Foundation for Research and Culture
- Hjiirnfonden
- Hagstreimer's Foundation Millennium
- Swedish Stroke Foundation
- Amleiv's Foundation
- NanoNet COST Action [BM1002]
- EU [237956, 279017]
- Fight for Sight [1421/22] Funding Source: researchfish
- Medical Research Council [1361541] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [16K08286] Funding Source: KAKEN
Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.
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