4.8 Article

Chemically Crosslinked Amphiphilic Degradable Shape Memory Polymer Nanocomposites with Readily Tuned Physical, Mechanical, and Biological Properties

期刊

ACS APPLIED MATERIALS & INTERFACES
卷 15, 期 2, 页码 2693-2704

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c19441

关键词

shape memory polymer; polyhedral oligomeric silsesquioxane; hydroxyapatite; macroporous scaffold; osteogenesis

向作者/读者索取更多资源

Facile surgical delivery and stable fixation of synthetic scaffolds are crucial for successful scaffold-guided tissue regeneration, along with degradability and bioactivity. Shape memory polymers (SMPs) with covalently integrated polyhedral oligomeric silsesquioxanes (POSSs) and urethane-crosslinked polylactide (PLA) show high strength and degradability at physiological temperatures. By tuning hydrophilicity, degradability, cytocompatibility, and osteoconductivity/osteoinductivity, these SMPs combined with hydroxyapatite (HA) can be potential synthetic bone grafts.
Facile surgical delivery and stable fixation of synthetic scaffolds play roles just as critically as degradability and bioactivity in ensuring successful scaffold-guided tissue regeneration. Properly engineered shape memory polymers (SMPs) may meet these challenges. Polyhedral oligomeric silsesquioxanes (POSSs) can be covalently integrated with urethane-crosslinked polylactide (PLA) to give high strength, degradable SMPs around physiological temperatures. To explore their potential for guided bone regeneration, here we tune their hydrophilicity, degradability, cytocompatibility, and osteoconductivity/ osteoinductivity by crosslinking star-branched POSS-PLA with hydrophilic polyethylene glycol diisocyanates of different lengths and up to 60 wt % hydroxyapatite (HA). The composites exhibit high compliance, toughness, up to gigapascal storage moduli, and excellent shape recovery (>95%) at safe triggering temperatures. Water swelling ratios and hydrolytic degradation rates positively correlated with the hydrophilic crosslinker lengths, while the negative impact of degradation on the proliferation and osteogenesis of bone marrow stromal cells was mitigated with HA incorporation. Macroporous composites tailored for a rat femoral segmental defect were fabricated, and their ability to stably retain and sustainedly release recombinant osteogenic bone morphogenetic protein-2 and support cell attachment and osteogenesis was demonstrated. These properties combined make these amphiphilic osteoconductive degradable SMPs promising candidates as next-generation synthetic bone grafts.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据