期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 48, 页码 53535-53545出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c17309
关键词
liquid-infused surfaces; omniphobic lubricant; hierarchically structured surfaces; antibacterial; antithrombogenic
资金
- Spanish Ministry of Science and Innovation for the FPI Grant [BES-2017-080057]
- NSERC Discovery Grant
- Ontario Early Researcher Award
- McMaster Start-up funds
Thrombus formation and bacterial adhesion are common causes of failure in blood-contacting medical devices. This study presents a polymeric lubricant-infused system with hierarchically structured micro/nano features that shows excellent repellent properties against blood stains and bacterial adherence. The developed material has the potential to prevent contamination in biomedical devices.
Thrombus formation and infections caused by bacterial adhesion are the most common causes of failure in blood-contacting medical devices. Reducing the interaction of pathogens using repellent surfaces has proven to be a successful strategy in preventing device failure. However, designing scale-up methodologies to create large-scale repellent surfaces remains challenging. To address this need, we have created an all-polymeric lubricant-infused system using an industrially viable swelling-coagulation solvent (S-C) method. This induces hierarchically structured micro/nano features onto the surface, enabling improved lubricant infusion. Poly(3,3,3-trifluoropropylmethylsiloxane) (PTFS) was used as the lubricant of choice, a previously unexplored omniphobic nonvolatile silicone oil. This resulted in all-polymeric liquid-infused surfaces that are transparent and flexible with long-term stability. Repellent properties have been demonstrated using human whole blood and methicillin-resistant Staphylococcus aureus (MRSA) bacteria matrices, with lubricated surfaces showing 93% reduction in blood stains and 96.7% reduction in bacterial adherence. The developed material has the potential to prevent blood and pathogenic contamination for a range biomedical devices within healthcare settings.
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