期刊
JOURNAL OF NEURAL TRANSMISSION
卷 123, 期 4, 页码 421-424出版社
SPRINGER WIEN
DOI: 10.1007/s00702-016-1524-7
关键词
Parkinson disease; PET; Olfaction; Dopamine; Aging
资金
- Michael J. Fox Foundation, Department of Veterans Affairs [I01 RX000317]
- NIH [P01 NS015655, RO1 NS070856, P50 NS091856]
There is wide variability in the reported prevalence rates of abnormal smell in Parkinson disease (PD). This study assessed the prevalence of abnormal smell, using the University of Pennsylvania Smell Identification Test (UPSIT), in 183 patients with PD with confirmed PET imaging evidence of nigrostriatal denervation. Impaired olfaction in this sample was nearly universal (97.8 %). Wide-ranging prior olfactory impairment estimates may reflect not only uncertainty regarding diagnostic classification, but also the use of inaccurate normative data and differences in olfactory tests used.
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