期刊
JOURNAL OF NATURAL PRODUCTS
卷 79, 期 1, 页码 132-140出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.5b00802
关键词
-
资金
- National Natural Science Foundation of China [21322204, 81172939]
- NSFC-Joint Foundation of Yunnan Province [U1302223]
- reservation-talent project of Yunnan Province [2011CI043]
- West Light Foundation of the Chinese Academy of Sciences
Thirty-two enmein-type ent-kaurane diterpenoids, including 13 new compounds, were isolated from the aerial parts of Isodon phyllostachys. Compounds 1 and 2 are the first examples of 3,20:6,20-diepoxyenmein-type ent-kauranoids, and the structures of these new compounds were established mainly by analyzing NMR and HREIMS data. The absolute configurations of 1 and 8 and the relative configuration of 9 were determined using single-crystal X-ray diffraction. Compounds 11, 15, 20, and 21 were active against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), with IC50 values ranging from 1.2 to 5.0 mu M. Compounds 3, 11, 15, 17, 20, 21, 25, and 29 strongly inhibited NO production in LPS-stimulated RAW264.7 cells, with IC50 values ranging from 0.74 to 4.93 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据