期刊
JOURNAL OF NATURAL PRODUCTS
卷 79, 期 4, 页码 1213-1218出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00051
关键词
-
资金
- National Science, Technology and Innovation Plan (MAARIFAH) the King Abdulaziz City for Science and Technology of the Kingdom of Saudi Arabia [11-ENV1540-03]
- Grants-in-Aid for Scientific Research [24120003] Funding Source: KAKEN
A mass spectrometry (MS)-guided isolation has led to the purification of a new cyanobactin, wewakazole B (1), along with the known compound curacin D from a Red Sea Moorea producens. The planar structure of 1 was elucidated using a combination of NMR and MS techniques. After ozonolysis and acid hydrolysis, the absolute configurations of the amino acid components of 1 were determined by chiral-phase LC-MS and HPLC analyses. Notably, compound 1 exhibited cytotoxic activity toward human MCF7 breast cancer cells (IC50 = 0.58 mu M) and human H460 lung cancer cells (IC50 = 1.0 mu M) and was also found to be inactive in a siderophore assay.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据