期刊
JOURNAL OF NATURAL PRODUCTS
卷 79, 期 7, 页码 1752-1761出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00137
关键词
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资金
- National Natural Science Foundation of China [81303266]
- Natural Science and Technology Foundation for Distinguished Young Scholars of Shanghai [13ZR1462000]
- Chen Guang Foundation of Shanghai Ministry of Education [13CG46]
- Science Foundation for the Excellent Youth Scholars of Ministry of Education of Shanghai [ZZszy13058]
- Foundation of Shanghai University of Traditional Chinese Medicine [2012JW05, 2013JW08]
Four new dihydroxanthone derivatives (1-4), four new tetrahydroxanthone derivatives (5-8), two new xanthone derivatives (9 and 10), and two known caged tetrahydroxanthones were isolated from extracts of the leaves of Garcinia oligantha by bioassay-guided fractionation. These structures of the new compounds were elucidated by NMR and MS spectroscopic data analysis, and the absolute configurations of compounds 1 and 5-7 were determined by electronic circular dichroism and/or single-crystal X-ray diffraction analysis. Compounds 6-9 were shown to be unusual xanthone derivatives with an isopropyl group, which was confirmed by the X-ray crystallographic structure of compound 8. The inhibitory activities of these isolates against four human tumor cell lines (A549, HepG2, HT-29, and PC-3) were assayed, and compounds 1, 2, 5, 11, and 12 showed inhibitory effects on tumor cell growth, with IC50 values ranging from 2.1 to 8.6 mu M.
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