期刊
JOURNAL OF NATURAL PRODUCTS
卷 79, 期 5, 页码 1415-1422出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00160
关键词
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资金
- Program for New Century Excellent Talents in University [NCET-13-0693]
- National Natural Science Foundation of China [81573572, 81503286, 81530097]
- Science and Technology Innovation Fund from Beijing Academy of Agriculture and Forestry Sciences [QNJJ201519]
Five new meroterpenoids, purpurogenolides A E (1-5), and four known metabolites (6-9) were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHz 111. The structures of the new meroterpenoids were elucidated by analysis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of 1 and 5 were determined by single-crystal X-ray crystallographic analysis, and those of 2-4 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compounds 2-4 and 6 showed inhibition of nitric oxide production in lipopolysaccharideactivated BV-2 microglial cells with IC50 values of 0.8-30.0 mu M.
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