期刊
JOURNAL OF NATURAL PRODUCTS
卷 79, 期 11, 页码 2814-2823出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00581
关键词
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资金
- Hungarian Scientific Research Fund (OTKA) [K109846]
- Janos Bolyai scholarship of Hungarian Academy of Sciences
- Hungarian National Research Foundation (OTKA) [K105871]
- Ministry of Science and Technology of Taiwan [NSC 102-2628-B-037-003-MY3, MOST 103-2320-B-037-005-MY2]
- Kaohsiung Medical University (Aim for Top Universities Grant) [KMU-TP104E39, KMU-TP104A26]
- Ministry of Health and Welfare of Taiwan [MOHW105-TDU-B-212-134007]
- Health and Welfare Surcharge of Tobacco Products
The present study has focused on an investigation of the antibacterial effects of Juncus inflexus and the isolation and identification of its active compounds. Eleven phenanthrenes were isolated from a methanolic extract of the roots. Four compounds (jinflexins AD, 14) are new natural products, while seven phenanthrenes [juncuenins A (5), B (6), and D (8), juncusol (7), dehydrojuncuenins A (9) and B (11), and dehydrojuncusol (10)] were isolated for the first time from the plant. Jinflexin D (4) is a dimer with an unprecedented heptacyclic ring system. The absolute configurations of the new compounds were determined by TDDFT-ECD calculations, and their enantiomeric purity was checked by chiral HPLC analysis. Extracts of different polarity (n-hexane, dichloromethane, and ethyl acetate) were evaluated for their antimicrobial effects against methicillin-resistant Staphylococcus aureus, extended-spectrum beta-lactamase (ESBL)-producing Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, multiresistant Acinetobacter baumannii, and Pseudomonas aeruginosa. The MIC values of the isolated compounds were determined by a microdilution method. Jinflexin B (2), juncusol (7), juncuenin D (8), and dehydrojuncuenin B (11) showed significant activity (MIC value range 12.5100 mu g/mL) against MRSA strains.
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