期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 16, 期 7, 页码 6970-6977出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2016.11382
关键词
Upconversion Nanoparticles; Curcumin; Drug Delivery System; Near-Infrared Light; Tumor Cells
类别
资金
- National Natural Science Foundation [81272568, 81301973]
- Three-year Action Plan for Further Development of Traditional Chinese Medicine of Shanghai [CC-3-3032]
In this work, an anticancer drug delivery system based on curcumin-conjugated NaYF4:Yb3+, ErYb3+ nanoparticles was developed. The as-prepared nanoconstruct consisting of uniform hexagonal nanoparticles with an average diameter of about 200 nm was synthesized. A natural photosensitizer curcumin was loaded onto the nanoparticles through covalent interaction and physical adsorption. Drug loading efficiency was calculated and it turns out a high loading capacity of the as-prepared nanoparticles. Cytotoxity experiments of carboxylic acid-functionalized UCNPs and curcumin-UCNPs were performed via MTT assay. The drug delivery system demonstrates the ability to be uptaken by three different kinds of cell lines (Human hepatocellular carcinoma Bel-7402 cells, Human SKOV-3 ovarian cancer cells and Human breast adenocarcinoma MCF-7 cells) and to generate reactive oxygen species upon the excitation of near-infrared light, so as to kill tumor cells. To sum up, such a drug delivery system exhibits good potential in cancer therapy.
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