期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 16, 期 1, 页码 144-151出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2016.12042
关键词
Biosensors; Graphene; 2D; Cell Detection; CVD
类别
资金
- AFOSR MURI [FA9550-09-1-0705]
- Cornell Center for Materials Research (CCMR) [DMR-1120296]
- National Science Foundation
Graphene has several unique physical, optical and electrical properties such as a two-dimensional (2D) planar structure, high optical transparency and high carrier mobility at room temperature. These make graphene interesting for electrical biosensing. Using a catalyst-free chemical vapor deposition (CVD) method, graphene film is grown on a sapphire substrate. There is a single or a few sheets as confirmed by Raman spectroscopy and atomic force microscopy (AFM). Electrical graphene biosensors are fabricated to detect large-sized biological analytes such as cancer cells. Human colorectal carcinoma cells are sensed by the resistance change of an active bio-functionalized graphene device as the cells are captured by the immobilized antibody surface. The functionalized sensors show an increase in resistance as large as similar to 20% of the baseline with a small number of adhered cells. This study suggests that the bio-functionalized electrical graphene sensors on sapphire, which is a highly transparent material, can potentially detect circulating tumor cells (CTCs) and monitor cellular electrical behavior while being compatible with fluorescence-based optical detection bioassays.
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