Total Synthesis of Marine-Derived Azole Resistant Antifungal Agent (-)-Melearoride A and Antibiotic (-)-PF1163B

A flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton present in their structure is described featuring two different routes, with good overall yield. The key synthetic reactions utilized include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia-Kocienski olefination.

Automated summary

A flexible stereoselective and convergent cum divergent approach to the synthesis of two 13-membered macrolides through a common skeleton is described. The synthesis is achieved using two different routes, resulting in a good overall yield. Key synthetic reactions include Keck allylation, Evans asymmetric methylation, Grubbs metathesis, and Julia-Kocienski olefination.