☆ 3.8 Article

A Versatile System for Comparing Methods for Determining Mutations in the TERT Gene Promoter as an Example of the Analysis of Tumor Lesions of the Central Nervous System

MOSCOW UNIVERSITY CHEMISTRY BULLETIN (2022)

Human TERT promoter mutations as a prognostic biomarker in glioma

Branka Powter et al.

Summary: TERT promoter mutations C228T and C250T are crucial in cancer, can be easily detected through liquid biopsies, and hold potential for personalized cancer therapy.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2021)

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Article Genetics & Heredity

The landscape and driver potential of site-specific hotspots across cancer genomes

Randi Istrup Juul et al.

Summary: This study utilized large sets of whole cancer genomes to study mutation hotspots, categorize site-specific hotspots, and provide a resource of annotated hotspots genome-wide. The research found an excess of hotspots in protein-coding and gene regulatory regions, as well as identified hotspots associated with cancer genes. Additionally, some hotspots showed clear signs of positive selection.

NPJ GENOMIC MEDICINE (2021)

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Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology