Predictive value of systemic immune-inflammation index in recurrent urethral strictures

Purpose: To investigate the predictive value of systemic immune-inflammation index (SII) in recurrence of urethral stricture in patients undergoing internal urethrotomy Methods: In this two-center, retrospective study, 703 patients who had internal urethrotomy for urethral stricture were included. Demographic, clinical, and laboratory characteristics and operative data were obtained. Two groups were formed from the patients as non-recurrent urethral stricture (n=490) and recurrent urethral stricture (n=213). Results: There was no significant difference in the mean age between the patients with and without recurrence. There was a significant difference in the mean SII values and albumin levels between the recurrence and non-recurrence groups (p = 0.001 and p = 0.006, respectively). Using a cut-off value of 252 for the SII; the sensitivity was 59.62%, the specificity was 70.41%, the positive predictive value was 46.69%, the negative predictive value was 80.05% and the accuracy was 67.14%, respectively. Statistically significant correlation was found between the presence of recurrence and the established cut-off value of the SII (p = 0.00 I and p < 0.01, respectively). The risk of recurrence was stated that 3.514 times higher in patients with a SII value of >= 252. Conclusion: Using the SII the inflammatory state of the urethral tissue can be evaluated. Thus the risk of recurrence after internal urethrotomy operation can be predicted. Open urethroplasty technique instead of DVIU in patients with high SII values may increase the surgical success rates.

Automated summary

This study aimed to investigate the predictive value of systemic immune-inflammation index (SII) in the recurrence of urethral stricture. The results showed significant differences in SII values and albumin levels between the recurrence and non-recurrence groups. Using a cutoff value of 252 for SII, the recurrence risk could be predicted with moderate accuracy. The study suggests that open urethroplasty may be more suitable for patients with high SII values to improve surgical success rates.