期刊
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
卷 8, 期 2, 页码 101-106出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/23971983221124180
关键词
Systemic sclerosis; diffuse cutaneous involvement; elastography; immunoglobulin; mRSS
类别
The use of immunoglobulin has shown efficacy in the treatment of different rheumatologic autoimmune systemic diseases. A study on immunoglobulin therapy for systemic sclerosis showed encouraging results in improving skin symptoms. We present a case of a young woman with rapidly progressive diffuse cutaneous systemic sclerosis who had significant skin improvement after one year of subcutaneous immunoglobulin treatment. A narrative literature review on alternative treatments for systemic sclerosis skin involvement, focusing on immunoglobulin use, was also carried out.
The use of immunoglobulin is a therapeutic option with increasing evidence of efficacy for different rheumatologic autoimmune systemic diseases. Some studies concerning immunoglobulin use in systemic sclerosis have been published with encouraging results. We present the case of a young woman diagnosed with rapidly progressive diffuse cutaneous systemic sclerosis, refractory to therapy with methotrexate and rituximab, which presented a relevant skin improvement after one year of subcutaneous immunoglobulin (2 g/kg cumulative monthly dose, refracted in weekly administrations). Furthermore, a narrative literature review of the evidence for alternative treatments with a focus on immunoglobulin use for systemic sclerosis skin involvement was carried out.
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