期刊
CARDIOVASCULAR PATHOLOGY
卷 24, 期 4, 页码 224-229出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.carpath.2014.12.003
关键词
Hypertension; Aquaporin 1; High salt; Valsartan; Angiotensin II receptor blocker; Cardiac injury
资金
- Chunmiao Cultivation Program for University Talents in Jilin Province [2013-352]
- National Natural Science Fundation of China [31100566, 81273421, 31101009]
- Youth Research Fund Project of Science and Technology Department of Jilin Province [20140520006JH]
- Training Program for Outstanding Young Talents in Jilin, Jilin Provincial Health Department Project [2011ZC029]
Hypertension is the most common risk factor for various cardiovascular and cerebrovascular diseases that affects approximately 61 million, or 25% of the population in United States. The dietary salt intake is one of the most important but modifiable factors for hypertension. In the current study, we aim to elucidate the role of aquaporin 1 in high-salt-induced hypertension and cardiac injuries and whether angiotensin II receptor blocker valsartan could ameliorate the effect of high salt on blood pressure. Mice were fed with normal diet, high-salt diet in the presence or absence of valsartan for 4 weeks. The body weight gain, feeding behavior, blood pressure, and cardiac pathology changes were monitored after 4 weeks. The expression of aquaporin 1, vascular endothelial growth factor, transforming growth factor beta 1, and basic fibroblast growth factor were analyzed using quantitative real-time polymerase chain reaction, Western blot, and immunohistochemical staining. Valsartan partially reversed the effects of high-salt diet on hypertension, cardiac injuries such as fibrosis and inflammatory cell infiltration, and inhibition of aquaporin 1 and angiogenic factors; valsartan alone did not exert such effects. The current data demonstrated that the reduction of cardiac aquaporin 1 and angiogenic factor expression level might be associated with high-salt-induced hypertension and cardiac injuries in mice, which could be ameliorated by angiotensin II receptor blocker treatment. (C) 2014 by Elsevier Inc. All rights reserved.
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