The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

Article Biochemistry & Molecular Biology

Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity

Irina Leonardi et al.

Summary: The spatial organization of gut mycobiota is associated with intestinal epithelial function, host-protective immunity, and mouse behavior.

CELL (2022)

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Article Gastroenterology & Hepatology

The fecal mycobiome in non-alcoholic fatty liver disease

Munevver Demir et al.

Summary: The study found that the fecal fungal composition of patients with non-alcoholic fatty liver disease (NAFLD) is associated with disease severity. Non-obese NAFLD patients have a distinct fungal ratio in their feces compared to other types of patients. Antifungal treatment in a mouse model can reduce liver damage from steatohepatitis.

JOURNAL OF HEPATOLOGY (2022)

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Article Biochemistry & Molecular Biology

Ensembl Genomes 2022: an expanding genome resource for non-vertebrates

Andrew D. Yates et al.

Summary: Ensembl Genomes provides access to non-vertebrate genomes complementing the vertebrate resources developed by the Ensembl project, creating one of the most comprehensive genomic resources globally. They are focused on reducing genome redundancy and improving gene annotation, pangenome analysis, data dissemination speed, and support for the microbial research community.

NUCLEIC ACIDS RESEARCH (2022)

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Article Gastroenterology & Hepatology

Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome

Benoit Chassaing et al.

Summary: In healthy adults, consumption of the synthetic emulsifier CMC was found to exacerbate postprandial abdominal discomfort, disrupt gut microbiota and metabolome composition, leading to reduced diversity, and possibly contributing to the development of chronic inflammatory diseases.

GASTROENTEROLOGY (2022)

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Article Multidisciplinary Sciences

Immune regulation by fungal strain diversity in inflammatory bowel disease

Xin Li et al.

Summary: The study reveals the rich genetic diversity of pathogenic Candida albicans strains in the colonic mucosa of patients with inflammatory bowel disease, with some strains having high immune-cell-damaging capacity (HD strains). These strains exacerbate intestinal inflammation in vivo through specific mechanisms, highlighting new insights into host-fungal interactions and potential diagnostic and therapeutic targets for inflammatory diseases.

NATURE (2022)

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Article Virology

Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses

Chisa Kobayashi et al.

Summary: A study found that fungus-derived exophillic acid can inhibit HBV infection by reducing the susceptibility of host cells to viral attachment. Exophillic acid interacts with the HBV receptor NTCP, impairs bile acid uptake, and exhibits anti-infection effects against HBV and HDV.

VIRUSES-BASEL (2022)

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Article Food Science & Technology

Polysaccharides from Agrocybe cylindracea residue alleviate type 2-diabetes-induced liver and colon injuries by p38 MAPK signaling pathway

Wenxue Sun et al.

Summary: This experiment investigated the mechanism of action of polysaccharides from Agrocybe cylindracea residue (PACR) in ameliorating liver and colon injuries induced by type-2 diabetes. The results showed that PACR could reduce oxidative damage and inflammatory response, restore lipid levels, decrease the level of liver and colon lesions, and function in protecting the liver and colon. The study suggests that PACR could be used as a supplement to decrease blood glucose, relieve T2DM, and reduce oxidative stress and inflammatory response by inhibiting the activation of the p38 MAPK signaling pathway.

FOOD BIOSCIENCE (2022)

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Article Gastroenterology & Hepatology

Population-Level Configurations of Gut Mycobiome Across 6 Ethnicities in Urban and Rural China

Yang Sun et al.

Summary: The study revealed significant variability in the human gut mycobiome across populations, with urbanization-related factors having the strongest impact on gut mycobiome variation, followed by geography, dietary habits, and ethnicity. Different fungal species showed differences in abundance and correlations in urban and rural populations.

GASTROENTEROLOGY (2021)

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Article Multidisciplinary Sciences

The fecal mycobiome in patients with Irritable Bowel Syndrome

A. Das et al.

Summary: Alterations in the gut mycobiome were found to be significantly different between patients with Irritable Bowel Syndrome (IBS) and control subjects, but not among clinical subtypes of IBS. The mycobiome changes were significantly associated with alterations in the bacteriome and metabolome, but did not show a link with dietary habits. Despite co-variation with bacterial components, the mycobiome presents limited therapeutic and diagnostic potential for IBS.

SCIENTIFIC REPORTS (2021)

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Article Microbiology

Lessons learned from the prenatal microbiome controversy

Martin J. Blaser et al.

Summary: Recent studies have shown that the prenatal environment is not sterile, with microbial communities present that can impact the development and health of the host. However, controversy surrounds the prenatal microbiome, focusing on issues of contamination and inconsistencies among different studies.

MICROBIOME (2021)

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Article Biochemistry & Molecular Biology

Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies

Itai Doron et al.

Summary: This study reveals the important role of gut commensal fungi in shaping the human antibody repertoire through CARD9-dependent induction of host-protective antifungal IgG. Candida albicans is the major inducer of antifungal immunoglobulin G (IgG) and provides protection against disseminated candidiasis.

CELL (2021)

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Article Biochemistry & Molecular Biology

Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22

Yanan Zhu et al.

Summary: Mice lacking Dectin-3 showed increased tumorigenesis and Candida albicans burden, leading to enhanced IL-22 production in innate lymphoid cells, highlighting the significance of commensal fungi in regulating host immunity and promoting tumorigenesis.

EMBO JOURNAL (2021)

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Article Gastroenterology & Hepatology

Fecal Mycobiota Combined With Host Immune Factors Distinguish Clostridioides difficile Infection From Asymptomatic Carriage

Yangchun Cao et al.

Summary: Our study identified significant differences in alpha and beta diversity between patients with CDI and asymptomatic carriers, with enrichment of Cladosporium and Aspergillus genera in carriers. The ratio of Ascomycota to Basidiomycota was notably higher in CDI patients. Using a combination of fungal operational taxonomic units and host immune markers in a random forest classifier achieved high performance in distinguishing CDI patients from carriers.

GASTROENTEROLOGY (2021)

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Article Nutrition & Dietetics

The intestinal mycobiota and its relationship with overweight, obesity and nutritional aspects

Ricardo Garcia-Gamboa et al.

Summary: This study found that specific types and concentrations of fungal communities in obese individuals are related to the development of obesity, and showed correlations with weight, fat mass, and other biochemical indicators.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2021)

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Article Multidisciplinary Sciences

Multi-kingdom ecological drivers of microbiota assembly in preterm infants

Chitong Rao et al.

Summary: The gut microbiota in preterm infants develops predictably, with the environment, host, and microorganism interactions all potentially shaping the dynamics. The study used multi-kingdom absolute abundance quantification to investigate the absolute dynamics of bacteria, fungi, and archaea in a cohort of preterm infants, uncovering microbial blooms, extinctions, and microbe-microbe interactions. The research reveals the centrality of interactions between microorganisms in shaping host-associated microbiota, providing insights for microbiota ecology and interventions.

NATURE (2021)

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Article Multidisciplinary Sciences

Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice

Umang Jain et al.

Summary: The study revealed that Debaryomyces hansenii fungus inhabits incompletely healed intestinal wounds of mice and inflamed mucosal tissues of CD patients, impairing colonic healing. Mechanistically, D. hansenii affects mucosal healing through the myeloid cell-specific type 1 interferon-CCL5 axis.

SCIENCE (2021)

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Article Cell Biology

Fecal Fungal Dysbiosis in Chinese Patients With Alzheimer's Disease

Zongxin Ling et al.

Summary: This study found altered taxonomic composition of the fecal fungal microbiota in AD patients, with specific fungi enriched or decreased. Key differential fungi such as Candida tropicalis and Schizophyllum commune were positively correlated with certain immune response markers, while Rhodotorula mucilaginosa showed negative correlation with TNF-alpha level. The analysis revealed potential implications for the etiopathogenesis of AD and improved diagnosis and treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Gut microbiota profiles and characterization of cultivable fungal isolates in IBS patients

Piero Sciavilla et al.

Summary: Studies on irritable bowel syndrome have mainly focused on the role of gut bacteria in modulating intestinal functions, but limited evidence suggests that gut fungal communities may also play a role. This study compared the gut microbiota of IBS patients with healthy subjects, revealing significant differences in microbial composition. The findings suggest a potential involvement of gut fungi in IBS.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Article Microbiology

Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease

Itai Doron et al.

Summary: sIgA in gut barrier protection plays a crucial role, with a portion induced and directed by intestinal fungi. sIgA can influence fungal morphotypes, regulating fungal commensalism, which might be dysregulated in patients with Crohn's disease.

NATURE MICROBIOLOGY (2021)

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Article Biology

The gut commensal fungus, Candida parapsilosis, promotes high fat-diet induced obesity in mice

Shanshan Sun et al.

Summary: The study found that the gut commensal Candida parapsilosis is a causative fungus for the development of high fat-diet induced obesity in mice, highlighting the therapeutic strategy targeting gut fungi. In addition, the results suggest that fungi could represent possible targets for combating obesity.

COMMUNICATIONS BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory Properties In Vitro and Hypoglycaemic Effects of Phenolics from Cultivated Fruit Body of Phellinus baumii in Type 2 Diabetic Mice

Kai Yang et al.

Summary: Research on the hypoglycemic effects of Phellinus baumii phenolics (PPE) in type 2 diabetes mellitus (T2DM) animal models shows promising results, indicating its potential as a dietary component for the prevention or management of T2DM. PPE exhibits anti-inflammatory properties and improves glucose metabolism by activating the IRS1/PI3K/AKT pathway in diabetic mice.

MOLECULES (2021)

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Review Microbiology

The human virome: assembly, composition and host interactions

Guanxiang Liang et al.

Summary: The human body hosts vast numbers of different viruses, collectively termed the 'virome'. Research on the human virome has highlighted the assembly, composition, and dynamics of the virome as well as host-virome interactions in health and disease. Viral community states can be associated with adverse outcomes for the human host, while others are characteristic of health.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Multidisciplinary Sciences

A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection

Chew Teng Tan et al.

Summary: Broad-spectrum antibiotics can induce the release of peptidoglycan fragments by commensal bacteria, leading to the invasive growth of C. albicans and systemic dissemination, which is a significant risk factor for infection.

NATURE COMMUNICATIONS (2021)

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Article Microbiology

Cross-kingdom inhibition of bacterial virulence and communication by probiotic yeast metabolites

Orit Malka et al.

Summary: A study revealed a new fungus-secreted metabolite that can inhibit bacterial communication and virulence, shedding light on the potential benefits of probiotic foods and maintenance of a healthy gut microbiome. The discovery of cross-kingdom interference in quorum sensing may play important roles in enabling microorganism co-existence in multi-population environments, such as probiotic foods and the gut microbiome. This finding may contribute to understanding the health benefits of probiotic products against bacterially associated diseases.

MICROBIOME (2021)

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Review Microbiology

Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities

Xiaoyan Wu et al.

Summary: Gut fungi are crucial in modulating various organ functions and may present new opportunities for treating human diseases.

MICROBIOME (2021)

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Article Biology

Gut mycobiota alterations in patients with COVID-19 and H1N1 infections and their associations with clinical features

Longxian Lv et al.

Summary: The study reveals that gut mycobiota dysbiosis occurs in both COVID-19 patients and H1N1-infected patients, and this dysbiosis does not improve until patients are discharged and no longer require medical attention.

COMMUNICATIONS BIOLOGY (2021)

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Article Oncology

Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy

Stephen L. Shiao et al.

Summary: Studies have shown that intestinal fungi play a role in regulating antitumor immune responses following radiation in mouse models of breast cancer and melanoma. Fungi and bacteria have opposite influences on these responses, with depletion of fungi enhancing responsiveness to radiation while depletion of bacteria reducing responsiveness. Elevated intratumoral expression of Dectin-1, a primary innate sensor of fungi, is negatively associated with survival in breast cancer patients.

CANCER CELL (2021)

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Article Immunology

Impact of gut fungal and bacterial communities on the outcome of allogeneic hematopoietic cell transplantation

Florent Malard et al.

Summary: In patients receiving allogeneic hematopoietic cell transplantation (alloHCT), higher bacterial diversity is associated with improved overall survival and disease-free survival, while high relative abundance of Candida albicans may result in lower survival rates.

MUCOSAL IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Adaptive immunity induces mutualism between commensal eukaryotes

Kyla S. Ost et al.

Summary: The study reveals the crucial role of adaptive immune response in suppressing harmful fungal effectors, benefiting both Candida albicans and its host. IgA plays a key role in targeting specific adhesins to suppress the pathogenic hyphal morphotype of Candida, promoting intestinal homeostasis.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

Benjamin M. Scott et al.

Summary: A synthetic yeast-based therapeutic has been developed to reduce intestinal inflammation, fibrosis, and dysbiosis in mouse models of colitis and enteritis. This therapy involves engineered yeast probiotics that can sense a pro-inflammatory molecule and generate a proportional self-regulated response aimed at its neutralization, potentially providing a new treatment for inflammatory bowel disease.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Metabolic impacts of cordycepin on hepatic proteomic expression in streptozotocin-induced type 1 diabetic mice

Kongphop Parunyakul et al.

Summary: Cordycepin may help prevent hepatic metabolism in T1DM by regulating the expression of energy-related proteins and UPS to maintain cell survival, as observed in the study on streptozotocin-induced T1DM mice. The improvement in liver function with cordycepin treatment was related to changes in metabolic pathways and protein expression. Further research is needed to explore the therapeutic potential of cordycepin in metabolic mechanisms.

PLOS ONE (2021)

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Review Genetics & Heredity

Gut Microbiome Alterations in COVID-19

Tao Zuo et al.

Summary: The gut microbiome in patients with COVID-19 undergoes significant alterations, including weakening of the microbial ecological network, decreased diversity, enrichment of opportunistic bacteria, fungi, and viruses, as well as reduction in abundance of symbiotic bacteria and bacteriophages. These changes are associated with disease severity and persistence even after recovery, hindering the reassembly of the gut microbiome. Further research is needed to fully understand the role of the gut microbiome in host immunity against SARS-CoV-2 infection and the long-term effects of COVID-19 on the gut microbiome.

GENOMICS PROTEOMICS & BIOINFORMATICS (2021)

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Article Medicine, General & Internal

Alterations of the gut mycobiome in patients with MS

Saumya Shah et al.

Summary: This study revealed alterations in the gut mycobiome of patients with multiple sclerosis compared to healthy controls, with Saccharomyces and Aspergillus being over-represented in the patient group. Different mycobiome profiles were associated with specific bacterial microbiome and immune cell subsets in the blood of patients. Further research is needed to explore the potential causal relationship between the mycobiome and multiple sclerosis, as well as its interactions with bacteria and autoimmunity.

EBIOMEDICINE (2021)

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Article Gastroenterology & Hepatology

Fungal lysozyme leverages the gut microbiota to curb DSS-induced colitis

Ida Sogaard Larsen et al.

Summary: Through oral administration of lysozyme derived from Acremonium alcalophilum, bowel function in diet-induced obesity and chemically induced colitis can be improved. Lysozyme dose-dependently alleviates intestinal inflammation in colitis-challenged mice, protects against microbiota encroachment and fasting hyperinsulinemia in obese mice. This indicates that lysozyme leverages the gut microbiota to enhance gut health and combat inflammation.

GUT MICROBES (2021)

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Review Gastroenterology & Hepatology

The role of gut mycobiome in health and diseases

Lin Zhang et al.

Summary: The gut microbiome contains microbes from different kingdoms, including bacteria, fungi, and viruses. Recent studies have shown that intestinal fungi play a crucial role in host immunity and inflammation. Advances in sequencing methods have improved our understanding of gut fungi in health and their impact on various diseases.

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2021)

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Article Immunology

Fungemia and other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements

Juha Rannikko et al.

Summary: The study assessed the association between the use of S. boulardii probiotic and Saccharomyces fungemia, finding a higher odds ratio among patients using the probiotic. Additionally, the study shed light on the scale of nonblood Saccharomyces culture findings linked to use of this probiotic.

EMERGING INFECTIOUS DISEASES (2021)

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Article Gastroenterology & Hepatology

The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn's Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation

Andrew Nelson et al.

Summary: Comparative analysis of fecal mycobiota in patients with CD and non-CD subjects revealed compositional changes in the gut mycobiota of CD patients, suggesting a potential role of fungi in the pathogenesis of CD. No NOD2 genotype-specific differences were observed in the fecal mycobiota.

JOURNAL OF CROHNS & COLITIS (2021)

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Letter Medicine, General & Internal

Washed microbiota transplantation for the treatment of recurrent fungal infection in a patient with ulcerative colitis

Xia Wu et al.

CHINESE MEDICAL JOURNAL (2021)

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Article Psychology, Developmental

Dysbiosis of Gut Fungal Microbiota in Children with Autism Spectrum Disorders

Rong Zou et al.

Summary: This study found overall changes in the gut fungal community of children with ASD compared to healthy controls. Specific genera such as Saccharomyces and Aspergillus showed significant differences between the two groups, indicating their potential involvement in the abnormal gut fungal community structure of ASD.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2021)

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Article Medicine, Research & Experimental

Candida albicans disorder is associated with gastric carcinogenesis

Mengya Zhong et al.

Summary: This study identified an imbalance of gastric fungal microbiome associated with gastric cancer, characterized by altered fungal composition and ecology. Candida albicans was found to be a potential fungal biomarker for gastric cancer, with significant differences in fungal structure and diversity between gastric cancer and control groups. The study suggests that C. albicans could mediate gastric cancer by reducing the diversity and richness of stomach fungi.

THERANOSTICS (2021)

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Article Gastroenterology & Hepatology

Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis

Sara Lemoinne et al.

GUT (2020)

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Review Multidisciplinary Sciences

Guided dietary fibre intake as a means of directing short-chain fatty acid production by the gut microbiota

Gerald W. Tannock et al.

JOURNAL OF THE ROYAL SOCIETY OF NEW ZEALAND (2020)

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Article Gastroenterology & Hepatology

The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease

Huikuan Chu et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Behavioral Sciences

Analysis of gut mycobiota in first-episode, drug-naive Chinese patients with schizophrenia: A pilot study

Xue Zhang et al.

BEHAVIOURAL BRAIN RESEARCH (2020)

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Article Microbiology

Age-Related Variation of Bacterial and Fungal Communities in Different Body Habitats across the Young, Elderly, and Centenarians in Sardinia

Lu Wu et al.

MSPHERE (2020)

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Article Microbiology

Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis

Irina Leonardi et al.

CELL HOST & MICROBE (2020)

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Review Genetics & Heredity

Yeasts as probiotics: Mechanisms, outcomes, and future potential

Swastik Sen et al.

FUNGAL GENETICS AND BIOLOGY (2020)

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Article Multidisciplinary Sciences

Intestinal fungi are causally implicated in microbiome assembly and immune development in mice

Erik van Tilburg Bernardes et al.

NATURE COMMUNICATIONS (2020)

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Review Immunology

Antifungal Peptides as Therapeutic Agents

Miguel Fernandez de Ullivarri et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Immunology

Overview of the Potential Role of Malassezia in Gut Health and Disease

Madeleine Spatz et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Cell Biology

Mycobiome in the Gut: A Multiperspective Review

Voon Kin Chin et al.

MEDIATORS OF INFLAMMATION (2020)

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Article Gastroenterology & Hepatology

Gut fungal dysbiosis and altered bacterial-fungal interaction in patients with diarrhea-predominant irritable bowel syndrome: An explorative study

Gaichao Hong et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

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Article Gastroenterology & Hepatology

Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge

Tao Zuo et al.

GASTROENTEROLOGY (2020)

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Article Cell Biology

Pretreatment with Antibiotics Impairs Th17-Mediated Antifungal Immunity in Newborn Rats

Pingi Wang et al.

INFLAMMATION (2020)

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Article Microbiology

Human-Gut-DNA Virome Variations across Geography, Ethnicity, and Urbanization

Tao Zuo et al.

CELL HOST & MICROBE (2020)

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Review Microbiology

The host-associated archaeome

Guillaume Borrel et al.

NATURE REVIEWS MICROBIOLOGY (2020)

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Article Multidisciplinary Sciences

Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance

Caitlin H. Kowalski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Microbiology

Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Bastian Seelbinder et al.

MICROBIOME (2020)

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Article Medicine, General & Internal

Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study

Ravinder Nagpal et al.

EBIOMEDICINE (2020)

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Article Multidisciplinary Sciences

Gut mycobiomes are altered in people with type 2 Diabetes Mellitus and Diabetic Retinopathy

Rajagopalaboopathi Jayasudha et al.

PLOS ONE (2020)

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Article Mycology

FungalTraits: a user-friendly traits database of fungi and fungus-like stramenopiles

Sergei Polme et al.

Summary: The article introduces a database FungalTraits to facilitate functional assignments and ecological interpretation of fungi, discussing the challenges between molecular identification of fungal diversity and knowledge of functional traits. Through the involvement of expert knowledge and tools, researchers reannotated a large number of fungal and Stramenopila genera, summarizing them into 17 lifestyle-related traits suitable for environmental studies.

FUNGAL DIVERSITY (2020)

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Article Gastroenterology & Hepatology

Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE2 to alcoholic hepatic steatosis

Shanshan Sun et al.

GUT MICROBES (2020)

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Article Multidisciplinary Sciences

The trans-kingdom battle between donor and recipient gut microbiome influences fecal microbiota transplantation outcome

Negin Kazemian et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans

Petra Bacher et al.

CELL (2019)

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Article Microbiology

Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models

Jose J. Limon et al.

CELL HOST & MICROBE (2019)

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Article Infectious Diseases

Sequestration inside the yeast vacuole may enhance Helicobacter pylori survival against stressful condition

Farideh Siavoshi et al.

INFECTION GENETICS AND EVOLUTION (2019)

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Article Gastroenterology & Hepatology

Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis

Sonja Lang et al.

HEPATOLOGY (2019)

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Review Immunology

Gut Mycobiota in Immunity and Inflammatory Disease

Xin V. Li et al.

IMMUNITY (2019)

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Article Multidisciplinary Sciences

Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans

Jack Guinan et al.

SCIENTIFIC REPORTS (2019)

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Review Microbiology

Fungal-Bacterial Interactions in Health and Disease

Wibke Krueger et al.

PATHOGENS (2019)

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Article Biochemistry & Molecular Biology

Fungi form interkingdom microbial communities in the primordial human gut that develop with gestational age

Kent A. Willis et al.

FASEB JOURNAL (2019)

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Review Genetics & Heredity

The role of fungi in C. difficile infection: An underappreciated transkingdom interaction

David Stewart et al.

FUNGAL GENETICS AND BIOLOGY (2019)

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Article Multidisciplinary Sciences

A sparse covarying unit that describes healthy and impaired human gut microbiota development

Arjun S. Raman et al.

SCIENCE (2019)

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Review Gastroenterology & Hepatology

Review article: fungal alterations in inflammatory bowel diseases

Siu Lam et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

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Article Medicine, General & Internal

Incidence of Bloodstream Infections, Length of Hospital Stay, and Survival in Patients With Recurrent Clostridioides difficile Infection Treated With Fecal Microbiota Transplantation or Antibiotics A Prospective Cohort Study

Gianluca Ianiro et al.

ANNALS OF INTERNAL MEDICINE (2019)

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Article Multidisciplinary Sciences

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

Berk Aykut et al.

NATURE (2019)

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Article Ecology

Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria

Anja Kombrink et al.

ISME JOURNAL (2019)

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Article Biotechnology & Applied Microbiology

Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi

Siddhika Pareek et al.

NPJ BIOFILMS AND MICROBIOMES (2019)

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Article Biochemistry & Molecular Biology

Eurotium cristatum, a potential probiotic fungus from Fuzhuan brick tea, alleviated obesity in mice by modulating gut microbiota

Dingding Kang et al.

FOOD & FUNCTION (2019)

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Article Gastroenterology & Hepatology

Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host

Francesco Strati et al.

BMC GASTROENTEROLOGY (2018)

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Review Medicine, General & Internal

Coeliac disease

Benjamin Lebwohl et al.

LANCET (2018)

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Article Gastroenterology & Hepatology

Reversal of visceral hypersensitivity in rat by Menthacarin®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation

S. Botschuijver et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2018)

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Article Multidisciplinary Sciences

Dysbiosis in the oral bacterial and fungal microbiome of HIV-infected subjects is associated with clinical and immunologic variables of HIV infection

Pranab K. Mukherjee et al.

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Molecular quantification and differentiation of Candida species in biological specimens of patients with liver cirrhosis

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CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi

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SCIENCE (2018)

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Letter Gastroenterology & Hepatology

Identification of Schizosaccharomyces pombe in the guts of healthy individuals and patients with colorectal cancer: preliminary evidence from a gut microbiome secretome study

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The gut mycobiome composition is linked to carotid atherosclerosis

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BENEFICIAL MICROBES (2018)

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Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

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Article Biochemistry & Molecular Biology

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

Niv Zmora et al.

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SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer

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IMMUNITY (2018)

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Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection

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NATURE COMMUNICATIONS (2018)

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Characterizing the Human Mycobiota: A Comparison of Small Subunit rRNA, ITS1, ITS2, and Large Subunit rRNA Genomic Targets

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Enterobacteriaceae are essential for the modulation of colitis severity by fungi

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The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

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NATURE COMMUNICATIONS (2018)

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Review Microbiology

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

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Mucosa-associated microbiota dysbiosis in colitis associated cancer

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Fungal microbiota dysbiosis in IBD

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GUT (2017)

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Dysbiosis signature of mycobiota in colon polyp and colorectal cancer

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EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2017)

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Fungal mitochondrial oxygen consumption induces the growth of strict anaerobic bacteria

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FUNGAL GENETICS AND BIOLOGY (2017)

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Intestinal Fungal Dysbiosis Is Associated With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats

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GASTROENTEROLOGY (2017)

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Letter Gastroenterology & Hepatology

Risks of Saccharomyces boulardii-Containing Probiotics for the Prevention of Clostridium difficile Infection in the Elderly

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Intestinal fungi contribute to development of alcoholic liver disease

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Gut Microbial Diversity Assessment of Indian Type-2-Diabetics Reveals Alterations in Eubacteria, Archaea, and Eukaryotes

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Early gut mycobiota and mother-offspring transfer

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New evidences on the altered gut microbiota in autism spectrum disorders

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The gut mycobiome of the Human Microbiome Project healthy cohort

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High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut

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The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway

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Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria

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Immunological Consequences of Intestinal Fungal Dysbiosis

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CELL HOST & MICROBE (2016)

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Sequence-based methods for detecting and evaluating the human gut mycobiome

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Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

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Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn's Disease

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Revised Estimates for the Number of Human and Bacteria Cells in the Body

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Altered gut microbiota in Rett syndrome

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Interspecies Interactions between Clostridium difficile and Candida albicans

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Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder

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α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice

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BLOOD (2015)

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Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn's Disease

James D. Lewis et al.

CELL HOST & MICROBE (2015)

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Fungi inhabiting the healthy human gastrointestinal tract: a diverse and dynamic community

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Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease

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INFLAMMATORY BOWEL DISEASES (2015)

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International Society of Human and Animal Mycology (ISHAM)-ITS reference DNA barcoding database-the quality controlled standard tool for routine identification of human and animal pathogenic fungi

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Dysbiosis of Fungal Microbiota in the Intestinal Mucosa of Patients with Colorectal Adenomas

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Obesity changes the human gut mycobiome

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SCIENTIFIC REPORTS (2015)

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Changes in the composition of intestinal fungi and their role in mice with dextran sulfate sodium-induced colitis

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SCIENTIFIC REPORTS (2015)

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Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial

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EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2014)

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Dysbiosis of Gut Fungal Microbiota is Associated With Mucosal Inflammation in Crohn's Disease

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Diet rapidly and reproducibly alters the human gut microbiome

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MycoCosm portal: gearing up for 1000 fungal genomes

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NUCLEIC ACIDS RESEARCH (2014)

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Quantitative evaluation of fungi of the genus Candida in the feces of adult patients with type 1 and 2 diabetes - a pilot study

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GUT PATHOGENS (2014)

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Bacterial and fungal viability in the preterm gut: NEC and sepsis

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ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2013)

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Role of the Mycobiome in Human Acute Graft-versus-Host Disease

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Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile

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Plant and Fungal Diversity in Gut Microbiota as Revealed by Molecular and Culture Investigations

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Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents

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Review Immunology

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Th17 Cells in Immunity to Candida albicans

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CELL HOST & MICROBE (2012)

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Interplay between the Gastric Bacterial Microbiota and Candida albicans during Postantibiotic Recolonization and Gastritis

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Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis

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Correlation between gastrointestinal fungi and varying degrees of chronic hepatitis B virus infection

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DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2011)

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Fungal Chitin from Asthma-Associated Home Environments Induces Eosinophilic Lung Infiltration

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Medically important bacterial-fungal interactions

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NATURE REVIEWS MICROBIOLOGY (2010)

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Prevention of Clostridium difficile infection with Saccharomyces boulardii: A systematic review

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CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)

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Role of Toll-like receptors in systemic Candida albicans infections

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FRONTIERS IN BIOSCIENCE-LANDMARK (2009)

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Fungi and inflammatory bowel diseases: Alterations of composition and diversity

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SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2008)

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UNITE:: a database providing web-based methods for the molecular identification of ectomycorrhizal fungi

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Regulation of Candida albicans morphogenesis by fatty acid metabolites

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INFECTION AND IMMUNITY (2004)

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Saccharomyces boulardii in maintenance treatment of Crohn's disease

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DIGESTIVE DISEASES AND SCIENCES (2000)

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The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

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