期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 224, 期 -, 页码 387-392出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molliq.2016.10.009
关键词
Ceftazidime; Hydroxypropyl-gamma-cyclodextrin; Inclusion complex; UV/vis; FT-IR; NMR; Molecular docking
The inclusion complex of ceftazidime (CF) with hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD) was prepared. The inclusion behavior and interactions of CF with HP-gamma-CD was carried out in both the solution and the solid state by UV/vis, FT-IR, NMR and molecular docking techniques. All the obtained information demonstrated the formation of CF-CD inclusion complex. The CF-CD inclusion complex exhibited different spectroscopic features and properties from CF. The results suggested that CF-CD inclusion complex was established with 1:1 stoichiometry. It was found that a part of CF molecule, the thiazole ring with sulfur and nitrogen atoms with C=O and C=N bands of CF was included in the HP-gamma-CD cavity. Also the solubility and stability of CF-HP-gamma-CD was significantly improved and consequently the bioavailability of CF through CF-CD inclusion complex was effectively improved over free CF. Based on the enhancement of absorbance of CF in the presence of HP-gamma-CD a sensitive spectroscopic method for the CF determination was developed. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据