期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 223, 期 -, 页码 209-216出版社
ELSEVIER
DOI: 10.1016/j.molliq.2016.08.035
关键词
Drug delivery systems; Caffeine; beta-Cyclodextrin; Ternary aqueous mixtures; Apparent molar volumes; Viscosity
资金
- Coimbra Chemistry Centre
- Fundacao para a Ciencia e a Tecnologia (FCT)
- Portuguese Agency for Scientific Research [UID/QUI/UI0313/2013]
- COMPETE
- FCT [SFRH/BPD/92851/2013]
The aim of this paper is to provide insight into the molecular mechanisms of inclusion complex formation along with the structural understanding of drug carrier molecule interactions in aqueous ternary systems including caffeine and beta-cyclodextrin. Apparent partial molar volumes (V-phi) were determined from density experimental measurements for the binary aqueous solutions of both beta-cyclodextrin and caffeine, as well as for the ternary aqueous solutions in the low concentration range (i.e., corresponding to the therapeutic applications in the drug-releasing field). Mathematical modelling of this apparent molar property, assuming inclusion complexes of 1:1 stoichiometry, allowed the estimation of the corresponding equilibrium constant. Information about the driving forces for the insertion of the caffeine into the beta-cyclodextrin molecule was derived from the volume changes. Interactions between aqueous solutes and/or solute solvent interactions taking place in the solutions were evaluated from the volumes of transfer, Delta V-phi.c, and the viscosity B coefficients of transfer, Delta B, for the caffeine from water to the different aqueous solutions of beta-cydodextrin. The measurements were carried out at the standard (298.15 +/- 0.01) K and the physiological (310.15 +/- 0.01) K temperatures. (C) 2016 Elsevier B.V. All rights reserved.
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