期刊
RESPIRATORY INVESTIGATION
卷 60, 期 5, 页码 720-724出版社
ELSEVIER
DOI: 10.1016/j.resinv.2022.06.005
关键词
Chronic obstructive pulmonary disease Lipid profile; Insulin-like growth factor-1; Muscle deficit; Physical activity level
资金
- AMED [JP17ek0210045, JP20ek0210112]
This study investigated the associations between serum biomarkers and muscle measurements as well as energy expenditure indices in patients with chronic obstructive pulmonary disease (COPD). The results showed that high-density lipoprotein cholesterol (HDL-C) levels were significantly correlated with muscle areas, densities, and total energy expenditure (TEE). Only low-density lipoprotein cholesterol (LDL-C) levels were correlated with physical activity level (PAL).
Background: Chronic obstructive pulmonary disease (COPD) is associated with low muscle mass and function caused by malnutrition and physical inactivity. We aimed to investigate possible associations between serum biomarkers and clinical traits including computed tomography-derived muscle measurements and energy expenditure indices in COPD. Methods: Total energy expenditure (TEE) was measured by the doubly labeled water method, while physical activity level (PAL) was calculated as TEE/basal metabolic rate. Cross-sections and densities of pectoralis, rectus abdominis, and erector spinae muscles were measured. Serum biomarkers included adiponectin, insulin-like growth factor-1, and high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol (C). Results: HDL-C levels were significantly correlated with all muscle areas, densities, and TEE. Only LDL-C levels were correlated with PAL. Conclusions: HDL-C level was a potential biomarker for trunk muscle volumes and functions, as well as total energy expenditure in COPD. (C) 2022 The Authors. Published by Elsevier B.V. on behalf of The Japanese Respiratory Society.
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