Lessons learned - Moving on from QST sensory profiles

Article Anesthesiology

Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic peripheral neuropathy: impact of preserved small nerve fiber function

Sunil M. Jain et al.

Summary: The study evaluated the safety and efficacy of ISC 17536 in patients with chronic painful diabetic peripheral neuropathy, did not meet the primary end point in the overall patient population, but showed statistically significant and clinically meaningful pain improvement in an exploratory subpopulation of patients.

PAIN (2022)

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Article Anesthesiology

No pain, still gain (of function): the relation between sensory profiles and the presence or absence of self-reported pain in a large multicenter cohort of patients with neuropathy

Julia Forstenpointner et al.

Summary: The study revealed that hypersensitivity symptoms, including hyperalgesia and allodynia, are present in patients with central and peripheral lesions of the somatosensory system, even if they do not report spontaneous pain. There was a difference in pain sensitivity between painful and painless neuropathic conditions, with hyperalgesia more common in painful mononeuropathy and hypoalgesia more pronounced in painful polyneuropathy.

PAIN (2021)

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Article Anesthesiology

Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy

Luis Matesanz et al.

Summary: The prevalence of neuropathic pain in patients with CTS is 80%, with increasing severity correlating with more pronounced deficits in symptom severity, functional deficits, somatosensory dysfunction, emotional well-being, and sleep quality.

PAIN (2021)

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Article Orthopedics

The association of sensory phenotype and concomitant mood, sleep and functional impairment with the outcome of carpal tunnel surgery

Donna L. Kennedy et al.

Summary: This study found a high prevalence of neuropathic pain in patients undergoing carpal tunnel release surgery, but significant improvements in sensory and functional abilities were observed at 3- and 6-months post-surgery. Factors such as pain-related worry, anxiety, and functional interference were significantly associated with surgical outcomes, suggesting they are important prognostic indicators in this surgical cohort.

BMC MUSCULOSKELETAL DISORDERS (2021)

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Article Anesthesiology