期刊
AJIDD-AMERICAN JOURNAL ON INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
卷 127, 期 6, 页码 473-484出版社
AMER ASSOC INTELLECTUAL and DEVELOPMENTAL DISABILITIES - AAIDD
DOI: 10.1352/1944-7558-127.6.473
关键词
Williams syndrome; intellectual disability; executive function; cognition; NIH Toolbox
资金
- Intramural Research Program of the National Institute of Mental Health
- National Heart, Lung, and Blood Institute
- [1ZICMH002961]
- [ZIAHL006210]
- [ZIAHL006212]
The NIHTB-CB is a useful tool for assessing cognitive abilities in individuals with intellectual disabilities, but its use in WS patients may be limited, as indicated by the performance on tasks such as Flanker and DCCS.
The NIH Toolbox Cognition Battery (NIHTB-CB) was developed for epidemiological and longitudinal studies across a wide age span. Such a tool may be useful for intervention trials in conditions characterized by intellectual disability (ID), such as Williams syndrome (WS). Three NIHTB-CB tasks, including two executive functioning (Flanker, Dimensional Change Card Sort) and one episodic memory (Picture Sequence Memory) task, were given to 47 individuals with WS, ages 4 to 50, to evaluate feasibility (i.e., proportion of valid administrations) in this population. Findings indicated that NIHTB-CB tests showed good feasibility. Flanker and DCCS age-corrected scores were negatively correlated with age and showed floor effects, indicating these scores may not be useful for quantifying performance on these NIHTB-CB tests in ID.
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