期刊
CLINICAL CASE REPORTS
卷 10, 期 9, 页码 -出版社
WILEY
DOI: 10.1002/ccr3.6360
关键词
chemoresistance; radiation therapy; squamous cell carcinoma; xeroderma pigmentosum
This article presents a clinical case of a 10-year-old girl with XP, who was successfully treated with radiation therapy for ocular tumor. The treatment was well-tolerated and resulted in good tumor response. Consequently, the use of radiation therapy in XP patients may need to be reconsidered.
Xeroderma pigmentosum (XP) is a rare genetic disease, which vital prognosis is conditioned by the occurrence of cancers essentially of the skin and ocular surfaces, requiring an early and adapted management. Radiation therapy (RT) is a very effective modality in the therapeutic arsenal alongside surgery, but it remains underused as it is wrongly considered to be deleterious for these patients. In this article, we report the case of a 10-years-old girl with XP treated with external beam RT for a squamous cell carcinoma (SCC) of the right ocular conjunctiva. The clinical tolerance was excellent and we obtained a good tumoral response. Therefore, the place of RT in these patients could/should be reconsidered, especially since these suspicions have still not been confirmed.
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