期刊
MOVEMENT DISORDERS CLINICAL PRACTICE
卷 10, 期 1, 页码 94-100出版社
WILEY
DOI: 10.1002/mdc3.13609
关键词
functional movement disorders; deep brain stimulation; surgery
FMD is a commonly under-recognized diagnosis that may occur more often in patients undergoing DBS, especially those with pre-morbid psychiatric conditions. The prevalence and number of cases varied across centers.
Background Functional movement disorders (FMD) are a commonly under-recognized diagnosis in patients with underlying neurodegenerative diseases. FMD have been observed in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD) and other movement disorders. The prevalence of coexisting FMD among movement disorder-related DBS patients is unknown, and it may occur more often than previously recognized. Methods We retrospectively assessed the relative prevalence and clinical characteristics of FMD occurring post-DBS, in PD and dystonia patients (FMD+, n = 29). We compared this cohort with age at surgery-, sex-, and diagnosis-matched subjects without FMD post-DBS (FMD-, n = 29). Results Both the FMD prevalence (0.2%-2.1%) and the number of cases/DBS procedures/year varied across centers (0.15-3.65). A total of nine of 29 FMD+ cases reported worse outcomes following DBS. Although FMD+ and FMD- manifested similar features, FMD+ showed higher psychiatric comorbidity. Conclusions DBS may be complicated by the development of FMD in a subset of patients, particularly those with pre-morbid psychiatric conditions.
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