期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 57, 期 1, 页码 33-43出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-16-0007
关键词
miR-1275; adipogenesis; ELK1; obesity
资金
- National Key Basic Research Program of China [2013CB530604]
- National Natural Science Foundation of China [81330067, 81300706]
- Natural Science Foundation of Jiangsu Province China [BK20130075]
- Talent Work Leading Group of Jiangsu Province [201104013]
Excessive adipocyte differentiation and proliferation are closely associated with the onset of obesity, which has been partially linked to microRNA expression. In previous studies, using miRNA microarray screening, we found that miR-1275 was significantly decreased in human mature adipocytes. In this study, we examined the role of miR-1275 in adipogenesis. Our results indicated that miR-1275 can inhibit the differentiation of human visceral preadipocytes without affecting their proliferation. ELK1, an E-twenty-six ( ETS)-domain transcription factor associated with adipocyte differentiation, was strongly suppressed by miR-1275 in human visceral adipocytes. This was demonstrated via a dual-luciferase reporter assay and pointed to ELK1 as a direct target of miR-1275. Furthermore, miR-1275 expression was significantly diminished in the visceral adipose tissue of overweight and obese human subjects accompanied by a negative correlation with body mass index. These results suggest that miR-1275 could play a future role in the management of obesity, as a novel therapeutic target or biomarker.
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