期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 58, 期 2, 页码 R87-R106出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-16-0189
关键词
organelle communication; mitochondria-associated membranes; calcium signaling; metabolic homeostasis; insulin resistance; type 2 diabetes mellitus; PP2A
资金
- INSERM
- Lund University
Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER-mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.
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