期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 428, 期 10, 页码 2186-2194出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2015.12.021
关键词
development; rRNA; translation; evolution; single molecule
资金
- National Institutes of Health [R01GM117177, R01HL119439]
Specialized ribosomes is a topic of intense debate and research whose provenance can be traced to the earliest days of molecular biology. Here, the history of this idea is reviewed, and critical literature in which the specialized ribosomes have come to be presently defined is discussed. An argument supporting the evolution of a variety of ribosomes with specialized functions as a consequence of selective pressures acting on a near-infinite set of possible ribosomes is presented, leading to a discussion of how this may also serve as a biological buffering mechanism. The possible relationship between specialized ribosomes and human health is explored. A set of criteria and possible approaches are also presented to help guide the definitive identification of specialized ribosomes, and this is followed by a discussion of how synthetic biology approaches might be used to create new types of special ribosomes. (c) 2015 The Author. Published by Elsevier Ltd.
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