期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 428, 期 9, 页码 1822-1832出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2016.01.024
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资金
- Boehringer Ingelheim Fonds
- Francis Crick Institute
- Cancer Research UK
- UK Medical Research Council
- Wellcome Trust
- Cancer Research UK [15852] Funding Source: researchfish
- The Francis Crick Institute
- Cancer Research UK [10065] Funding Source: researchfish
The MCM motor of the CMG helicase powers ahead of the eukaryotic replication machinery to unwind DNA, in a process that requires ATP hydrolysis. The reconstitution of DNA replication in vitro has established the succession of events that lead to replication origin activation by the MCM and recent studies have started to elucidate the structural basis of duplex DNA unwinding. Despite the exciting progress, how the MCM translocates on DNA remains a matter of debate. (C) 2016 Published by Elsevier Ltd.
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