期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 91, 期 -, 页码 134-140出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2015.12.018
关键词
MMP; Signaling; Extracellular matrix; Systems biology; Proteomics; Extracellular matridomics
资金
- National Institutes of Health HHSN [268201000036C, N01-HV-00244, HL075360, GM114833]
- Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development [5101BX000505]
- American Heart Association Postdoctoral Grant and Scientist Development Grant [14POST18770012, 15SDG22930009]
- [P01HL051971]
- [P20GM104357]
Despite current optimal therapeutic regimens, approximately one in four patients diagnosed with myocardial infarction (MI) will go on to develop congestive heart failure, and heart failure has a high five-year mortality rate of 50%. Elucidating mechanisms whereby heart failure develops post-MI, therefore, is highly needed. Matrix metalloproteinases (MMPs) are key enzymes involved in post-MI remodeling of the left ventricle (LV). While MMPs process cytokine and extracellular matrix (ECM) substrates to regulate the inflammatory and fibrotic components of the wound healing response to MI, MMPs also serve as upstream signaling initiators with direct actions on cell signaling cascades. In this review, we summarize the current literature regarding MMP roles in post-MI LV remodeling. We also identify the current knowledge gaps and provide templates for experiments to fill these gaps. A more complete understanding of MMP roles, particularly with regards to upstream signaling roles, may provide new strategies to limit adverse LV remodeling. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据