期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 98, 期 -, 页码 28-36出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2016.07.002
关键词
Myocardial infarction; Early healing; Remodeling; Antidepressant; Citalopram; Mice
资金
- Bundesministerium fur Bildung and Forschung (BMBF) through the Comprehensive Heart Failure Center [01EO1004, 01EO1504]
- Deutsche Forschungsgemeinschaft (DFG) [SFB 688, TRR 58]
Aims: Both anxiety and depression are common and independent outcome predictors in patients after myocardial infarction (MI). However, it is unclear whether and how anti-depressants influence remodeling after MI. Thus, we studied cardiac remodeling in mice after experimental MI under treatment with citalopram, a selective serotonin reuptake inhibitor widely used as antidepressant. Methods and results: Treatment with citalopram versus saline was applied via osmotic pump after coronary artery ligation. Two different groups were studied: early treatment during the healing phase (starting immediately after surgery), or late treatment in the remodeling phase (starting 7 days after surgery). Late treatment did not change mortality or left ventricular remodeling after MI over the period of 6 weeks. However, in the early treatment group mortality was increased in citalopram-treated mice predominantly due to left ventricle rupture without differences in infarct size. Remodeling 4 weeks after Ml was not altered by the treatment. Neither infiltration of inflammatory cells, as determined by FAGS analysis of myocardial tissue, nor mRNA-expression of inflammatory cytqkines changed 3 days after MI in the early treatment group. However, extracellular matrix functioning was altered: There was a significant increase of MMP13 in citalopram treated animals after MI. Pretreatment with the MMP inhibitor PD 166793 prevented left ventricular ruptures and demonstrated a tendency to improved survival after citalopram treatment. Conclusions: Treatment with antidepressant citalopram in the acute but not in the late phase after MI significantly increased mortality in mice by disturbing early healing. Pharmacological MMP inhibition partially reversed the deleterious effects of citalopram. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据