Dataset of ileum bacterial diversity in mice after heart failure due to pressure overload

We recently reported the correlation of gut bacterial diver-sity with heart failure using a mouse model of heart failure due to pressure overload induced by transverse aortic con-striction (TAC). We found that gut the bacterial diversity is significantly altered and is directly correlated to the sever-ity of heart failure (Heart Failure Severity Closely Correlates with Intestinal Dysbiosis and Subsequent Metabolomic Al-terations (Spehlmann, 2022). In addition, stool samples that were collected for the gut microbial diversity analysis, we dissected ileum from the mice after 42 days of TAC. The total DNA was extracted to identify the bacterial diversity resided in ileum using 16S rRNA gene amplicon shotgun sequencing and downstream bioinformatics analysis to determine if it is correlated to the heart failure. (c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

Automated summary

This study reports the correlation between gut bacterial diversity and heart failure. The results from a mouse model experiment show that the severity of heart failure is closely correlated with gut bacterial diversity.